Protein phosphatase 2A (PP2A) is one of the most abundant intracellular serine/threonine (Ser/Thr) phosphatases accounting for 1% of the total cellular protein content. PP2A is comprised of a heterodimeric core enzyme and a substrate-specific regulatory subunit. Potentially, at least seventy different compositions of PP2A exist because of variable regulatory subunit binding that accounts for va...

S16020-2, a new olivacine derivative and a topoisomerase II inhibitor, has recently entered clinical trials. New analogues and derivatives have been synthesized from the S16020-2 compound. Preliminary data indicate that S30972-1, one of these S16020-2 derivatives, may exhibit a comparatively higher level of antitumor potency associated with an improved therapeutic index than does S16020-2. The ...

Lits, Kirschbaum, and Strong (2), using a transplantable lymphosarcoma in mice, found that colchicine would apparently cause complete re gression in some animals but that recurrence in evitably occurred. One of the most successful at tempts in treating a transplanted lymphosarcoma was reported by Heilman and Kendall (3). They showed that Compound E (ll-dehydro-17-hydroxycorticosterone) produced...

Sperner’s bound on the size of an antichain in the lattice P(S) of subsets of a finite set S has been generalized in three different directions: by Erdős to subsets of P(S) in which chains contain at most r elements; by Meshalkin to certain classes of compositions of S; by Griggs, Stahl, and Trotter through replacing the antichains by certain sets of pairs of disjoint elements of P(S). We unify...

The lymphocyte subpopulations, T and B-lymphocytes, and their re sponses to mitogenic stimulations in the peripheral blood, the bone marrow, and the thvmus were analvsed in the patients with mvasthenia vravis. The lymphocytes were isolated on 'Ficoll-Conray 400' gradient. The T lymphocytes were identified by the sheep red blood cell-rosette-formation, and the B-lymphocytes by the surface immuno...

The aim of this study was to verify subacute oral dose toxicity of positively charged 100 nm zinc oxide (ZnO(AE100[+])) nanoparticles (NPs) in Sprague-Dawley rats. ZnO(AE100[+]) NPs were administered to rats of each sex by gavage at 0, 500, 1,000, and 2,000 mg/kg/day for 14 days. During the study period, clinical signs, mortality, body weight, food consumption, hematology, serum biochemistry, g...

L 'anatomie ct la pathologie du systeme lymphatique sont discutees a la lumieres des etudes lymphographiques. Ces etudes ont surtout demontre l'indeoendance relative des deux systemes lymphatiques superficiel et profond et lamplexite des anomalies que l'en rencontre a leur niveau. Les lymphoedeme primaires sont distangues. Les nouvel­les tec'.111iques operatoires employees pour le traitement de...