back ground: vincristine (vcr), is a chemotherapy drug, useful in the treatment of leukemia, lymphoma and solid tumor and it is a potent neurotoxin and sensory neuropathy drug which a common behavioral toxicity of this drug. neuropathy is common squeal of intensive chemotherapy protocols that contain vincristine and corticosteroids. materials and methods: this study was a retrospective and desc...

acute lymphoblastic leukemia (all) is the most prevalent hematological malignant tumor during childhood. unilateral infiltration into the gums is less prevalent and more often observed in the aml type. a 12-year-old girl with symptoms of pain and swelling in the buccal vestibule and also at the posterior part of the right palate of the maxilla was referred to a private dental office. the patien...

background: the frequency of the multi-drug resistance 1 (mdr1) gene c3435t polymorphism differs in various ethnical populations such as asian, african, and caucasians populations. a silent c3435t polymorphism in exon 26 of mdr1 has been reported to be associated with a decreased expression of p-gp in tt genotypes carriers compared with cc genotypes carriers. materials and methods: to evaluate ...

background: the aim of this study was to detect the prognostic significance of survivin level and the expression of total p53 in acute lymphoblastic leukemia (all) and its correlation to patients' outcome. methods: sixty two children newly diagnosed with acute lymphoblastic leukemia were treated with chemotherapy and followed up for 2 years or until death. twenty apparently healthy volunteers w...

in many acute leukemias, normal differentiation does not occur. however, in many cell lines derived from hematologic malignancies, differentiation or apoptosis can be induced by variety of agents. despite advances in the treatment of acute lymphoblastic leukemia (all), in most patients long-term survival rates remain unsatisfactory, especially in t-cell derived all. thus we studied the anti-can...

Background: Previous studies have pointed to the major role of viruses in pathogenesis cancers, especially lymphoproliferative cancers. Objectives: The current study investigated relationship between recent Human Herpesvirus Type 6 (HHV6) infection and childhood leukemia-lymphoma syndrome. Methods: From January 2011 December 2012, we entered every new case acute lymphoblastic leukemia, non-Hodg...

Discrete diagnostic subtypes of T lymphoblastic leukemia/lymphoma (T-cell acute lymphoblastic leukemia/lymphoma, T-ALL) have historically not been widely recognized. Recently, a novel subset with distinctive immunophenotypic, molecular, and clinical features has been proposed. Termed early T-cell precursor acute lymphoblastic leukemia (ETP-ALL), these cases seem to correspond to a very early st...

BACKGROUND The expression of HER2/neu in B-cell acute lymphoblastic leukemia has been reported in previous studies. OBJECTIVE The objective of this research was to study the expression of HER2/neu on the blasts of patients with acute leukemia from the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. METHODS From June 2015 to February 2016, a HER2/neu monoclonal antibody ...

1. Reiter A, Schrappe M, Luwdig WD, et al. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. Blood 1994; 84:3122-33. 2. Wan JH, Trainor KJ, Brisco MJ, Morley AA. Monoclonality in B-cell lymphoma detected in paraffin wax embedded using the polymerase chain reaction. J Clin Pathol 1990; 43:888-90. 3. Brisco...

The 2008 World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues introduced a new category for myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1. Many of these cases present as a myeloproliferative neoplasm, usually with eosinophilia. However, neoplasms associated with rearrangement of PDGFRA can present as acute...