lymphocytes are responsible for the decrease in the LDL receptor in familial hypercholesterolemia. In this study, we empleyed FITC-conjugated LDL for the receptor assay. This approach could differentiate LDL-binding lymphocytes clcarly from Iymphocytes not bearing LDL. These LDLbinding lymphocytes howed the characteristics of B cells. A B cell rich population carried LDL, while a T cell rich po...

BACKGROUND The prognostic values of tumor-infiltrating lymphocytes (TILs) and TILs subsets in breast cancer (BC) are uncertain. METHODS A systematic literature search (MEDLINE, Web of Science, EMBASE, and the Cochrane Library to August 2014) was conducted for studies which met the eligibility criteria. The primary clinical outcome was defined as disease-free survival (DFS), overall survival (...

Peritoneal exudates induced in rats infected with Listeria monocytogenes contain sensitized lymphocytes which can protect normal recipients against a Listeria challenge. The protective cells arise in lymphoid tissue remote from the peritoneal cavity. Those formed in the caudal lymph nodes of subcutaneously infected rats are delivered to the thoracic duct and hence to the blood from where they a...

Lymphocyte recirculation facilitates the detection and elimination of pathogens and the dissemination of immunologic memory. It is generally assumed that all small lymphocytes in the blood are actively recirculating, yet there is little quantitative data directly comparing the migration of this population with actively recirculating, lymph-derived lymphocytes. In this study blood lymphocytes we...

In recent years a major thrust in immunology has been to clarify the morphological, surface, and functional properties of the complex populations comprising the lymphoid cell series. At the core of the problem is the mechanism of lymphocyte "activation," the process by which specific antigens or nonspecific agents stimulate resting lymphocytes to transform morphologically (1-5) and to exhibit a...

PURPOSE To evaluate Fas expression on CD4 and CD8 T cells in each organ at each stage of experimental autoimmune uveoretinitis (EAU) and apoptotic cells within EAU eyes. METHODS Rats were immunized with the uveitopathogenic peptide derived from interphotoreceptor retinoid-binding protein. Flow cytometry was performed in ocular cells, draining lymph nodes cells and splenic cells of EAU rats to...

In radiobiology circulating T-lymphocytes are used as “natural biodosimeters” since the frequency of chromosomal aberrations that occur in them after radiation exposure is proportional to accumulated dose. addition, stable (translocations) detected years and decades exposure. Estimation doses lymphocytes requires consideration two dose components: by lymphocyte precursors (progenitors) red bone...

Background/Aim: Knowledge of Coronavirus 19 (COVID19) pathogenetic mechanisms is necessary to provide new treatment strategies. This study aims assess how oncological disease impacts on the clinical course COVID-19 patients. Patients and Methods: From 1st March 30th April 2020, 96 patients were classified according outcome as severe (n=67) moderate (n=29). Demographic data...

This paper analyses the results of immunological examinations of 124 patients with thermal injury. We examined indices of peripheral blood such us the size of the population of circulating T-lymphocytes (CD3), T-helpers (CD4), T-suppressors (CD8 and CD25), natural cell killers (CD16), transmembrane protein of apoptotic activity (CD16), B-lymphocytes, phagocyte activity of lymphocytes, and the l...

In six patients with Epstein-Barr virus (EBV) induced infectious mononucleosis (IM) and in two patients with IM-like syndrome, peripheral blood lymphocytes in the acute and convalescent phase were tested for human la-like antigens as well as other cell surface markers. The major population of T lymphocytes in the acute phase showed la-like antigens, as detected by indirect immunofluorescence wi...