OBJECTIVE To record various clinicopathological characteristics of breast cancer (BC) in our population and to find an association between these characteristics and axillary nodal metastasis. METHODS This cross-sectional study included 150 BC patients from two tertiary care centers in Karachi from 15(th) February, 2013 to 31(st) March, 2015. Frequencies, percentages, and odds ratio were estim...

Breast cancer is one of the most common types of cancer found in women in Dr. Sardjito General Hospital Jogjakarta, Indonesia. Most of those patients were in the stage IIB and high grade (Aryandono et al., 2000). Prognosis of breast cancer is determined by several clinicapathological parameters which is also can be used to predict the natural history of this cancer. The presence or absence of l...

Statistical analysis included a bivariate analysis of the association between BRAF mutation status and patient and disease features, including age, sex, tumor size, lymph-node metastases, extrathyroidal extension, multifocality, lymphovascular invasion, involvement of surgical margins, and AJCC stage. Multivariate logistic-regression analyses of these features were conducted to examine which pr...

I read the article by Jung et al. [1] regarding histomorpho-logical factors predicting the response to neoadjuvant chemo-therapy (NAC) in triple-negative breast cancer. They concluded that independent predictors of pathologic complete response after NAC were a higher number of tumor-infiltrating lymphocytes (p = 0.007), absence of clear cytoplasm (p = 0.008), low levels of tumor necrosis (p= 0....

BACKGROUND Lymphovascular invasion (LVI) in colorectal cancer (CRC) is considered a strong stage-independent prognostic factor and influences decisions regarding adjuvant chemotherapy in patients with stage II tumors. However, the degree of interobserver agreement among pathologists for LVI in CRC is largely unknown. This study was undertaken to examine such interobserver variability, and we hy...

OBJECT To assess the effects of lymphovascular space invasion (LVSI) on cancer recurrence and survival in patients with primary epithelial ovarian cancer. METHODS A retrospective study was conducted of patients with stage I-IV primary epithelial ovarian cancer who underwent cytoreductive surgery. LVSI is defined as the presence of tumor cells within an endothelium-lined space, and the patient...

The aim of this study was to investigate immune response and its prognostic significance in colon carcinomas using the previously described Immunoscore (IS). A population-based series of 779 colorectal cancers, operated on between 2000 and 2010, were classified according to tumour, node, metastasis (TNM) status, mismatch repair (MMR), and BRAF mutation status. Rectal cancer cases (n = 203) were...

BACKGROUND Axillary lymph node status is one of the most important prognostic factors for breast cancer. The aim of this study was to determine predictive factors for metastasis to sentinel node (SN) in primary invasive breast cancer. METHOD This is a study of 3979 patients with primary breast cancer during 2008-2013 in Malmö and Lund scheduled for surgery and included in the information retr...