نتایج جستجو برای: lynch syndrome
تعداد نتایج: 623651 فیلتر نتایج به سال:
After the discovery of Lynch syndrome in the 1960s [1], its definition started from hereditary nonpolyposis colorectal cancer (HNPCC) specifically focusing affected organs. However, affected organs include nearly the whole body the endometrium, ovary, ureter, stomach, pancreas, biliary system, small bowel, brain, and skin. The past several decades have shifted our focus from organs to genes. In...
Chromosome 8q23.3, 10p14 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome – a combined analysis of the Australian, Dutch and Polish Lynch syndrome cohorts Bente A Talseth-Palmer, Juul T Wijnen, Ingvild S Brenne, Shantie Jagmohan-Changur, Katie A Ashton, Carli M Tops, Tiffany-Jane Evans, Mary McPhillips, Claire Groombridge, Janina Suchy, Grzegorz Kurzawski, The Dutch Cancer G...
Lynch syndrome is a genetic disease that often develops in patients with endometrial cancer and is caused by abnormal DNA mismatch repair (MMR) genes. In the United States, it was recently reported that the prevalence of Lynch syndrome with an hMSH2 mutation in patients with endometrial cancer in the lower uterine segment (LUS) is much greater tha...
The Lynch syndrome (hereditary nonpolyposis colorectal cancer [HNPCC]), is the most common form of hereditary colorectal cancer (CRC), accounting for 2% to 7% of all CRC cases. The next most common hereditary CRC syndrome is familial adenomatous polyposis (FAP), which accounts for less than 1% of all CRC. Lynch syndrome is of crucial clinical importance due to the fact that it predicts the life...
PURPOSE Molecular screening techniques are available to identify hereditary Lynch syndrome in people with newly diagnosed colorectal cancer (CRC). We aimed to determine whether decisions of patients or clinicians reduced detection of Lynch syndrome. PATIENTS AND METHODS A prospective cohort of 245 consecutive individuals with mismatch repair-deficient CRC recruited from a population-based mol...
AIM To assess the feasibility of Microsatellite Instability (MSI) analysis in uterine cavity washings for detecting endometrial cancer in Lynch syndrome. MATERIALS AND METHODS This was a proof-of-concept study in Lynch syndrome patients, scheduled for hysterectomy. At the beginning of surgical procedure, uterine cavity washings were performed, and sent for MSI analysis. Pathological examinati...
Utility of endometrial sampling prior to risk-reducing hysterectomy in a patient with Lynch syndrome
Occult endometrial cancer is occasionally discovered in women with Lynch syndrome undergoing risk-reducing hysterectomy. The case presented here demonstrates that preoperative endometrial sampling can help detect these occult cancers; however, there are currently no recommendations for this preoperative intervention. A 50-year-old woman with Lynch syndrome underwent endometrial sampling prior t...
This article explores the views of general practitioners and specialists on their referral of patients with suspected Lynch syndrome to cancer genetic services. Using a purposive maximum variation sampling strategy, we conducted semi-structured interviews face-to-face with 28 general practitioners and specialists in public or private hospitals and specialist clinics between March and August 201...
BACKGROUND The most frequent hereditary colorectal cancer (CRC) syndromes are Lynch syndrome and familial adenomatous polyposis (FAP), accounting for approximately 5% of the CRC burden. Both are characterized by an autosomal dominant mode of transmission and require an individualized approach of intensified screening and prophylactic surgery. METHODS In this review, we provide an overview of ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید