A resting culture of Rhizopus arrhizus (ATCC 11145) transformed verrucarin A into 16-hydroxyverrucarin A, whereas R. arrhizus transformed verrucarin B into a mixture of 16-hydroxyverrucarin B and 3'-hydroxyverrucarin A. Relative to verrucarins A and B, the 16-hydroxy derivatives showed marked increases in activity, as tested in vivo against P388 mouse leukemia.

A polycatenated HOF has been constructed from supramolecular embraced pairs of macrocyclic modules, featuring fluorescent detection nitrobenzene in water.

A modular synthetic approach was developed in which variation of the triplets of building blocks used enabled systematic variation of the macrocyclic scaffolds prepared. The approach was demonstrated in the synthesis of 17 diverse natural product-like macrocyclic scaffolds of varied (12-20-membered) ring size. The biological relevance of the chemical space explored was demonstrated through the ...

A new macrocyclic ligand (H2L) was synthesized by reaction of Acenaphthoquinone and oaminophenol. Then, its Co (II), Ni (II), Cu (II), Zn (II) and Cd (II) complexes were synthesized by the condensation method. Macrocyclic ligand (H2L) and Co(NO3)2.6H2O, Ni(NO3)2.6H2O, Cu(NO3)2.6H2O, ZnCl2.2H2O and CdCl2.2H2O respectively. The ligand and its complexes have been characterized by IR, H, UV–Vis spe...

Azacalix[5]pyridine, a heteroatom bridged calixaromatic with an odd number of arene units, and azacalix[10]pyridine, a giant molecular belt, were selectively synthesized based on a 2 + 3 macrocyclic coupling strategy; both novel macrocyclic hosts formed strong 1 : 1 complexes with fullerenes C60 and C70 in a size-selective manner with association constants up to 1.3 x 10(5) +/- 0.03 x 10(5) M(-1).

introduction, topologically constrained azamacrocycles, defined as macrocycles having additional bridges besides the basic parent ring between nitrogen atoms donors, will be discussed. Special attention will be paid to a unique class of macrocycles consisting of cross-bridged macrocyclic ligands having added components of topological and rigidity constraints. These impart exceptional kinetic an...

Tetraaza Macrocyclic complexes of transition metals of Ni (II), Cu(II), Cr(III), Fe(III), Mn(II) were synthesized in methanolic media by template method. The complexes were characterized by elemental analysis, UVVis, Infrared spectroscopy. In vitro antibacterial activity of macrocyclic complexes against five bacteria i.e. Streptococcus mutans, Escherichia coli, Staphylococcus aureus, Streptococ...

A new chiral stationary phase (CSP) was prepared by attachment of macrocyclic glycopeptide antibiotic eremomycin to the epoxy-activated silica under mild conditions. In contrast to CSP with immobilized vancomycin, which is a close structural analogue of eremomycin, the prepared CSP reveals high enantioselectivity for separation of amino acids enantiomers. It was demonstrated by the example of r...

Macrocyclic complexes of Mn, Co and Cu via Schiff base reactions. These 12membered tetradentate N6-macrocyclic complexes were characterized by elemental analysis, conductance, magnetic susceptibility measurements and the spectral studies like IR spectra, Electronic spectra and NMR spectra.Thus, themacrocyclic ligand coordinates through imine and secondary amine nitrogens of the macrocyclicring....