The inference of gene regulatory networks is a core problem in systems biology. Many inference algorithms have been proposed and all suffer from false positives. In this paper, we use the minimum description length (MDL) principle to reduce the rate of false positives for best-fit algorithms. The performance of these algorithms is evaluated via two metrics: the normalized-edge Hamming distance ...

The minimum description length (MDL) principle states that one should prefer the model that yields the shortest description of the data when the complexity of the model itself is also accounted for. MDL provides a versatile approach to statistical modeling. It is applicable to model selection and regularization. Modern versions of MDL lead to robust methods that are well suited for choosing an ...

We have characterized the binding of trans-1-(2,5-dimethoxyphenyl)-3-[4-(dimethylamino)phenyl]-2-methyl-2- propen- 1-one (MDL 27048) to purified procine brain tubulin, and the inhibition of microtubule assembly by this compound in vitro and using cultured cells. Binding measurements were performed by difference absorption and fluorescence spectroscopy. MDL 27048 binds to one site/tubulin hetero...

The two most popular model selection rules in the signal processing literature have been the Akaike’s criterion AIC and the Rissanen’s principle of minimum description length MDL. These rules are similar in form in that they both consist of data and penalty terms. Their data terms are identical, but the penalties are different, the MDL being more stringent toward overparameterization. The AIC p...

BACKGROUND Tracheal intubation can be associated with considerable hemodynamic changes, particularly in patients with uncontrolled hypertension. The GlideScope(®) video-laryngoscope (GVL) is a novel video laryngoscope that does not need direct exposure of the vocal cords, and it can also produce lower hemodynamic changes due to lower degrees of trauma and stimuli to the oropharynx than a Macint...

Probabilistic programs provide an appealing language for describing mental theories, because they are Turing complete: any computable process may be described as a program. Program induction is the problem of inferring theories, in the form of (probabilistic) programs, that describe some set of observations. Minimum Description Length, or MDL, is one common approach to program induction [11]. T...

This paper introduces a Minimum Description Length (MDL) principle to de ne tness functions in Genetic Programming (GP). In traditional (Koza-style) GP, the size of trees was usually controlled by user-de ned parameters, such as the maximum number of nodes and maximum tree depth. Large tree sizes meant that the time necessary to measure their tnesses often dominated total processing time. To ov...

MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and induced cell death in a concentration-dependent manner. At a moderate concentration (~20 µM), MDL-12330A mainly induced apoptotic death wher...

In this paper we present a part of Casl-Mdl, a visual modelling notation based on Casl-Ltl (an extension for dynamic system of the algebraic specification language Casl). The visual constructs of Casl-Mdl have been borrowed from the UML, thus existing editors may be used. A Casl-Mdl model is a set of diagrams but it corresponds to a Casl-Ltl specification, thus Casl-Mdl is a suitable means to e...

The replacement of amino acids 1 and 3 of glycopeptide antibiotics (dalbaheptides) with new amino acids or other chemical entities suitable to interact with both glycopeptide-resistant (D-Ala-D-Lactate) and susceptible (D-Ala-D-Ala) targets is one of the chemical strategies currently followed to pursue activity against highly glycopeptide-resistant VanA enterococci while maintaining activity ag...