Fluoroquinolones, sulfonamides and macrolides were analyzed in soil samples collected from suburban areas in Tianjin, China. Fluoroquinolones were the predominant class of antibiotics. The mean total concentration of fluoroquinolones (33.56 μg/kg) was 30-fold higher than one of macrolides, which were the second dominant class antibiotics. Sulfonamides showed the lowest level in soil. The spatia...

Clarithromycin or azithromycin is not infrequently used as empiric treatment for upper respiratory tract infections. When patients develop a rash after several days of treatment, one is often faced with the diagnostic dilemma of whether this is a drug eruption or viral exanthema. Most times, if the temporal sequence is in keeping with a drug eruption, this patient will be peremptorily labelled ...

Macrolide antibiotics are known to have a different proarrhythmic potential in the presence of comparable QT prolongation in the surface ECG. Because the extent of QT prolongation has been used as a surrogate marker for cardiotoxicity, we aimed to study the different electrophysiological effects of the macrolide antibiotics erythromycin, clarithromycin, and azithromycin in a previously develope...

BACKGROUND Resistance to antimicrobial agents among Staphylococcus aureus is an increasing problem. Two common genes responsible for resistance to macrolide, lincosamide and streptogramin B (MLSB) antibiotics are the ermA and ermC genes. Three resistance phenotypes have been detected to these antibiotics: strains containing cMLSB (constitutive MLSB) and iMLSB (inducible MLSB), which are resista...

OBJECTIVES To determine the association between a diagnosis of sensorineural hearing loss (SNHL) and the prescription of a macrolide antibiotic. STUDY DESIGN Retrospective nested case-control study. METHODS From the LifeLink (IMS, Danbury, CT) health claims database, we randomly selected a cohort of subjects 15 to 60 years old from 2006 to 2014. Cases were identified as patients diagnosed w...

Background: Antibiotics called macrolide, lincosamide and streptogramin B (MLSB) are being used to treat staphylococci infections. Multiple pathways that impart resistance to MLSB antibiotics have been confirmed to cause clinical failure. The present work aimed to determine the frequency of constitutive and inducible clindamycin resistant among coagulase-negative staphylococci (CoNS) isolates o...

Macrolide antibiotics are categorized by the WHO as Highest Priority, Critically Important Antimicrobials due to their recommendation treatment for severe cases of campylobacteriosis in humans; a self-limiting, rarely life-threatening, zoonotic foodborne infection. Low rates macrolide resistance Campylobacter jejuni and availability alternative treatments have prompted some regulatory schemes a...

Macrolide antibiotics, such as erythromycin, bind to the nascent peptide exit tunnel (NPET) of bacterial ribosome and modulate protein synthesis depending on sequence. Whereas in vitro biochemical structural methods have been instrumental dissecting explaining molecular details macrolide-induced peptidyl-tRNA drop-off stalling, dynamic effects drugs ongoing inside live cells are far less explor...

The tylCK region of the Streptomyces fradiae genome was sequenced, revealing an incomplete set of five tylC genes encoding all-but-one of the enzymes involved in the biosynthesis of mycarose. The latter is a 6-deoxyhexose sugar required during production of the macrolide antibiotic, tylosin. The missing mycarose-biosynthetic gene, tylCVI, was found about 50 kb distant from its functional partne...

In the elderly, calcium-channel blockers are the first-line treatment for hypertension, and macrolides are commonly prescribed antibiotics. Here we report a 78-year-old man taking nifedipine, diltiazem and carvedilol who presented with persistent hypotension and bradycardia after clarithromycin was prescribed. He was diagnosed with drug-induced hypotension and treated with fluid resuscitation a...