There is accumulating evidence that workplace exposure to toxic substances contributes to male infertility. Men suffering from infertility problems may do well to look at their occupations, where exposure to certain substances may be a contributory factor, if not a direct cause, of infertility. Most of the studies to date are either case reports or epidemiological studies (population-based, cas...

The present study was undertaken to evaluate the endocrinal causes of infertility in women .Infertility affects 10-15% 0f couples 0f reproductive age groups and female factor is responsible for 40 – 50 %of cases , most common causes of female infertility are ovulatory dysfunction and thyroid hormone ,and estrogen ,progesterone ,and serum Prolactin dysfunction . Estimation of estrogens,progester...

according to different geographical conditions, human health in different sub-regions of the world and cultural differences, the male factor infertility has heterogeneous causes in the world. this study was performed in an attempt to clarify the associated factors which might play a role in this respect in a group of iranian infertile men. this study was a cross - sectional, descriptive and ret...

Approximately 15% of couples in the reproductive age group worldwide are affected by infertility, and it is estimated that about 40-50% of infertilities are of male origin. Genetic factor accounts for 10-15% of severe male infertility, including chromosomal aberrations and single gene mutations (Ferlin et al, 2006). After the Klinfelter syndrome, Y chromosomal microdeletions are the most freque...

Cytokines have been important mediators of the immunity and can be involved in numerous processes in the male genital tract including acting as immunomodulatory elements within the male gonad. The aims of this study were: 1) to detect pro- and anti-inflammatory cytokine levels in the control group and subgroups of infertile men; and 2) to set up the practical recommendations concerning determin...

Stochastic, environmentally and/or genetically induced disturbances in the genome-wide epigenetic reprogramming processes during male germ-cell development may contribute to male infertility. To test this hypothesis, we have studied the methylation levels of 2 paternally (H19 and GTL2) and 5 maternally methylated (LIT1, MEST, NESPAS, PEG3, and SNRPN) imprinted genes, as well as of ALU and LINE1...

Several studies showed that the genetic mutations in the folate-related enzyme genes might be associated with male infertility; however, the results were still inconsistent. We performed a meta-analysis with trial sequential analysis to investigate the associations between the MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G mutations and the MTHFR haplotype with the risk of male infertility. O...

Infertility, considered as one of the main public health issues, affects about 10%-15% of the couples in reproductive age. Male factors are known to be responsible for 50% of all infertilities. It is well-established that the chromosomal abnormality is more prevalent in infertile men than in fertile men [1]. In developed countries, the incidence factor is considered to be less, when compared to...