نتایج جستجو برای: manf

تعداد نتایج: 147  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Johann Soret Nadia Bakkour Sophie Maire Sébastien Durand Latifa Zekri Mathieu Gabut Weronika Fic Gilles Divita Christian Rivalle Daniel Dauzonne Chi Hung Nguyen Philippe Jeanteur Jamal Tazi

The prevalence of alternative splicing as a target for alterations leading to human genetic disorders makes it highly relevant for therapy. Here we have used in vitro splicing reactions with different splicing reporter constructs to screen 4,000 chemical compounds for their ability to selectively inhibit spliceosome assembly and splicing. We discovered indole derivatives as potent inhibitors of...

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