This investigation was designed to determine whether nano-sized manganese oxide (Mn-40 nm) particles would induce dopamine (DA) depletion in a cultured neuronal phenotype, PC-12 cells, similar to free ionic manganese (Mn(2+)). Cells were exposed to Mn-40 nm, Mn(2+) (acetate), or known cytotoxic silver nanoparticles (Ag-15 nm) for 24 h. Phase-contrast microscopy studies show that Mn-40 nm or Mn(...

The present study examines the effects of divalent and trivalent Manganese (Mn(2+)/Mn(3+)) mixture inhalation on mice to obtain a novel animal model of Parkinson disease (PD) inducing bilateral and progressive dopaminergic cell death, correlate those alterations with motor disturbances, and determine whether L-DOPA treatment improves the behavior, to ensure that the alterations are of dopaminer...

The crystal structure of di-μ(3)-chlorido-tetra-μ(2)-chlorido-dichloridoocta-(imidazole-κN)tetra-manganese(II) ethanol 1.234 solvate, [Mn(4)Cl(8)(C(3)H(4)N(2))(8)]·1.234C(2)H(5)O or [Mn(4)Cl(8)(Him)(8)]·1.234EtOH, where Him is imidazole (C(3)H(4)N(2)), is based upon two Mn(4)Cl(4) cubes which share one face, and which each lack one manganese vertex, giving a Mn(4)Cl(6) unit. This contains two d...

Effects of imidazoles and substituted pyridines and pure s-donors on the oxidation of cyclooctene with NaIO4 by 5,10,15,20-tetraphenylporphyrinato-manganese(III) acetate, Mn(TPP)OAc, and 5,10,15,20-Tetramesitylporphyrinato-manganese(III) acetate, Mn(TMP)OAc, catalysts in CH2Cl2-H2O solvent are studied. Coordination of the nitrogen donors to the Mn...

These studies were designed to determine the relative bioavailability and tolerance of tribasic Mn chloride (TBMC) for growing broiler chickens. In experiment 1, birds were fed a basal diet (starter, 102 ppm; grower, 209 ppm) or the basal diet supplemented with 3,600, 4,500, or 5,400 ppm Mn from either TBMC or manganese sulfate (MnSO(4)), and BW, feed intake, and plasma Mn were measured. In exp...

Background It is thought that the interaction of genetic and environmental factors is an important risk factor for Parkinson’s disease (PD). a-Synuclein (a-syn) is a protein of special interest in PD because mutations in a-syn (A53T or A30P or E46K) lead to PD. Manganese (Mn) is a heavy metal known to cause parkinsonian symptoms. Therefore, we investigate the effect of manganese (Mn) on human a...

The use of the highly sterically demanding Cp(BIG) ligand (Cp(BIG) = C5(4-nBuC6H4)5) and white phosphorus (P4) enables the synthesis of new P-rich derivatives of the rare Pn ligand complexes of manganese. The obtained complexes, [{Cp(BIG)Mn}2(μ,η(5:5)-P5)] (2) and [{Cp(BIG)Mn}2(μ,η(2:2)-P2)2] (3), exhibit the highest number of P atoms in this class of manganese compounds identified by X-ray str...

The present study aims to identify the impact of polluted aquatic body i.e. River Hindon on two selected riparian flora i.e. Azadirachta indica and Acacia nilotica. During the course of study the average concentration of different metals in river water was found as Iron (Fe) 11.27ppm±3.50, Manganese (Mn) 4.00ppm±1.26, Cadmium (Cd) 0.08ppm±0.07, Nickel (Ni) 0.63ppm±0.17 and Zinc (Zn) 1.46ppm±0.3...

A general approach for the synthesis of manganese-doped II-VI and III-V nanowires based on metal nanocluster-catalyzed chemical vapor deposition has been developed. High-resolution transmission electron microscopy and energy-dispersive X-ray spectroscopy studies of Mn-doped CdS, ZnS, and GaN nanowires demonstrate that the nanowires are single-crystal structures and homogeneously doped with cont...

Deinococcus radiodurans is extremely resistant to ionizing radiation. How this bacterium can grow under chronic gamma radiation [50 grays (Gy) per hour] or recover from acute doses greater than 10 kGy is unknown. We show that D. radiodurans accumulates very high intracellular manganese and low iron levels compared with radiation-sensitive bacteria and that resistance exhibits a concentration-de...