Mantle cell lymphoma and other lymphoma subtypes often spread to the bone marrow, and stromal interactions mediated by focal adhesion kinase frequently enhance survival and drug resistance of the lymphoma cells. To study the role of focal adhesion kinase in mantle cell lymphoma, immunohistochemistry of primary cases and functional analysis of mantle cell lymphoma cell lines and primary mantle c...

The goal of this study was to obtain a complete description of the elastic modulus and hysteresis of the mantle tissue of the squid Loligo pealei over the entire functional region of the mantle. In addition, in vivo strains were measured to allow calculations of the amount of energy stored and returned in each region of the mantle studied, and microscopic analysis of the tissue was carried out ...

We have computed focal residual spheres for 145 subduction zone earthquakes along the northwest edge of the Pacific using regional and global mantle velocity models from tomographic nversions. The mantle models explain much of the observed residual sphere data and, to a certain extent, suggest the location of mantle velocity heterogeneities which are responsible for various residual sphere patt...

Introduction: Water is thought to be vital for the development of plate tectonics because it lowers viscosities in the asthenosphere and enables subduction. However, the following issue persists: if water is necessary for plate tectonics, but subduction itself hydrates the upper mantle, how is the upper mantle initially hydrated? Here we present models demonstrating that processes associated wi...

Oxygen and iron isotope analyses of low-Ti and high-Timare basalts are presented to constrain their petrogenesis and to assess stable isotope variations within lunar mantle sources. An internally-consistent dataset of oxygen isotope compositions of mare basalts encompasses five types of low-Ti basalts from the Apollo 12 and 15 missions and eight types of high-Ti basalts from the Apollo 11 and 1...

I apply array processing techniques to study the slowness and coda of P/Pdiff for 1,371 shallow earthquakes (< 200 km) that occurred in Asia, South America, Tonga-Fiji, and Indonesia, and were recorded by the medium-aperture array, YKA, in Canada. The slowness analysis shows lateral variations in Earth structure at the base of the mantle across the north Pacific. I observe an Ultra-Low Velocity...

[1] Subduction zones alter the upper plate in a variety of ways, including metasomatism via slab-derived fluids and accretion of exotic terranes. These processes should produce distinctive seismic signatures, as seismic velocities are sensitive to compositional variations. A new method is developed to estimates depths to interfaces and Poisson’s ratio (Vp/Vs ratio) for dipping layered structure...

In Africa volumetrically minor, mid-plate volcanic rocks of Cenozoic age are concentrated in areas affected by Pan-African (500 _+ 150 Ma) crustal reactivation, and are virtually absent from cratonic areas. We interpret this as indicating that Pan-African areas are underlain by fertile lithospheric mantle and cratons by depleted lithospheric mantle, and propose a model to explain both the distr...

Molluscs fabricate shells of incredible diversity and complexity by localized secretions from the dorsal epithelium of the mantle. Although distantly related molluscs express remarkably different secreted gene products, it remains unclear if the evolution of shell structure and pattern is underpinned by the differential co-option of conserved genes or the integration of lineage-specific genes i...

[1] We investigate the physics of multiscale convection in Earth’s mantle, characterized by the coexistence of large-scale mantle circulation associated with plate tectonics and smallscale sublithospheric convection. In part 2 of our study, the temporal and spatial evolution of sublithospheric convection is studied using two-dimensional whole mantle convection models with temperatureand depth-d...