Risk-based approach is used for examination of impact of different factors on quality of medicinal products in technology transfer. A general diagram is offered for risk analysis execution in technology transfer from pharmaceutical development to production. When transferring technology to full- scale commercial production it is necessary to investigate and simulate production process applicati...

This paper is concerned with the make-or-buy decision model for manufacturing and procurement problems. We develop a web-based two-step approach such as: 1) the first step, we used the multi-attribute analysis method using AHP(analytic hierarchy process) and 2) second step we used fuzzy set ranking methodologies to integrate the special decision problems that are the problems of multiobjective,...

Dispatching rules are usually applied to schedule jobs in Flexible Manufacturing Systems (FMSs) dynamically. Despite their frequent use, one of the drawbacks that they display is that the state the manufacturing system is in dictates the level of performance of the rule. As no rule is better than all the other rules for all system states, it would highly desirable to know which rule is the most...

In this paper we describe an ontology for a model of manufacturing scheduling problems to be solved on the web, through several different scheduling methods made available by a web scheduling decision support system. This approach aims enabling to share scheduling knowledge and methods, in a globally distributed context, in order to facilitate solving these problems, either in the industry or i...

Integrating subsystems of manufacturing processes, material flow, organization and information to form a manufacturing system is vital to a smooth and responsive operation in the dynamic market. This article presents an integrated system framework for product design optimization in terms of cost, quality and reliability considerations, which are mapped onto the computer integrated manufacture –...

This paper proposes an efficient algorithm to evaluate system reliability for many real-life systems such as manufacturing, telecommunication and computers systems. A multicommodity stochastic-flow network is constructed to model a manufacturing system in which each node stands for a machine station, and each arc stands for a transmission medium (shipping machine or conveyor). Four characterist...

The industrial manufacturing of insulating parts must meet strict requirements in order to be used in disturbed environments. Experts know that the moulding process has an impact on the final product quality. However, the phenomenon is so complicated that the relation between the manufacturing process and the product quality is difficult to identify. Some non-destructive methods are nowadays us...

A novel manufacturing strategy based on continuous processing integrated with online monitoring tools coupled with efficient automatic feedback control system is highly desired for efficient Quality by Design (QbD) based manufacturing of the next generation of pharmaceutical products with optimal consumption of time, space and resources. In this manuscript, an efficient plant-wide control strat...

This thesis presents an automated method for assessing conceptual designs with respect to manufacturing and supply chain, using geometric data mining and machine learning algorithms. It is important for designers to understand how design decisions will impact downstream manufacturing and sourcing. Many critical decisions are made during conceptual design that impact production cost even before ...

In many everyday situations, we bias our perception from the top down, based on a task or an agenda. Frequently, this entails shifting attention to a specific attribute of a particular object or scene. To explore the cost of shifting top-down attention to a different stimulus attribute, we adopt the task-set switching paradigm, in which switch trials are contrasted with repeat trials in mixed-t...