Abstract— In order to determine factory capacity or necessary time to reach a desired quota, the manager of a multi-product batch manufacturing system must know the best method of scheduling for the factory. To determine the optimal scheduling, we first create a model of the factory. This model is used to simulate the factory. Using this simulation and an integer programming formulation, we det...

The increasing number of challenging new chemical entities in development coupled with the pressure to reduce R&D and production costs have created the perfect storm in the pharmaceutical industry. Using a science-based approach to excipient selection will allow you to overcome challenges such as poor bioavailability and stability while optimizing the formulation using the manufacturing process...

Investigation of a cyanate ester based formulation and stereolithography-based additive manufacturing via Hot Lithography to produce polycyanurates with glass transition temperature 336 °C without any additives.

Probabilistic design to address uncertainty and variability has been approached from many different angles, by different communities. While reliability methods focus on probability of constraint satisfaction or violation, robust design methods have focused primarily on the level of performance variation, the sensitivity of design objectives. “Six Sigma” quality concepts have arisen more recentl...

A generalization of Arakawa and Schubert’s convective quasi-equilibrium principle is presented for a closure formulation of mass-flux convection parameterization. The original principle is based on the budget of the cloud work function. This principle is generalized by considering the budget for a vertical integral of an arbitrary convection-related quantity. The closure formulation includes Ar...

Additive Manufacturing (AM) has many advantages, but the lack of access to knowledge associated with it minimises its development in industry. The design phase is crucial for success AM, a challenge Design (DfAM) methods therefore facilitate and manipulation this knowledge. This transfer can be achieved by formalising rules at all scales, communicating them designer appropriate phase. It hence ...

Many researchers over time have stressed the importance of incorporating the manufacturing perspective in the formulation of business strategy. Prior work in this area has tended to focus primarily on the involvement of the manufacturing executive in strategic decision making processes, while relatively little attention has been given to the level of influence enjoyed by the manufacturing execu...

Adoptive immunotherapy using gene-modified T cells redirected against cancer has proven clinical efficacy and tremendous potential in several medical fields. However, such personalized medicine faces several challenges in the complexity associated with the current clinical manufacturing methods, which hampers dissemination. Conventionally, the preparation of autologous genemodified T cells comp...