Background and objectivePTEN-induced putative kinase 1 (PINK1) is a mitochondrial that regulates mitophagy. PINK1-deficient mAPP mice display low LC3B levels, PINK1 overexpression enhances autophagy increases the expression level of lysosome-associated membrane protein (LAMP1). The present study evaluated whether altered could modulate β-amyloid (Aβ)-treated mitophagy in PC12 cells, simple cell...

Angiotensin I-converting enzyme inhibitors (ACEi) cause both chronic and acute side effects, including rare but potentially life-threatening angioedema (AE). The main hypothesis to be tested in this study was that metallopeptidases and kinin receptors are present in oropharyngeal tissues and that their expression is modulated by ACEi and inflammation. Novel real-time polymerase chain reaction a...

Healthy living is an increasingly important topic on the agenda of policy makers. Containment of health care cost through public health and specific prevention programs is seen as a key element of the current social-economic policies in the western world. mHealth technology holds the promise to make healthy living more effective than traditional prevention programs. As part of a broad healthy l...

Problemática: la desigualdad de género se da en todos los entornos. Para el caso estudio, organizaciones economía solidaria, contexto prácticas asociacionistas del ámbito rural, departamento Meta, municipio Lejanías, cual ha sido afectado por violencia. Objetivos: determinar incidencia procesos cognitivos planificación y toma decisiones solidaria con enfoque Lejanías (Colombia, 2020). Materiale...

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Figure 1 Electroanatomic activation map during RA stimulation (A) before and (B) after MAP ablation. Signals obtained at the ablation catheter located at the free lateral wall are shown. MAP anatomical disposition (yellow dots). Right bundle branch anatomical disposition (blue dots). M =mahaim accessory pathway potential; MAPd = distal ablation catheter recording; MAPp = proximal ablation cathe...

Amyloid-β (Aβ) deposition is one of the hallmarks of the amyloid hypothesis in Alzheimer's disease (AD). Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts of the disease. The extent to which the data from mice can be transferred to man remains controversial. Several studies have shown convincing treatment results in reducing Aβ an...