نتایج جستجو برای: marker validation
تعداد نتایج: 301287 فیلتر نتایج به سال:
The recent implementation of the Revised Bathing Water Directive in the European Union has highlighted the need for development of effective methods to differentiate between sources of faecal contamination. It had previously been shown that amplification of 16S rRNA genes of host-specific Bacteriodales species using the HF183F and CF128F primers could be used as markers for human and bovine fae...
PREMISE OF THE STUDY Single-nucleotide polymorphism (SNP) marker discovery in plants with complex allotetraploid genomes is often confounded by the presence of homeologous loci (along with paralogous and orthologous loci). Here we present a strategy to filter for SNPs representing orthologous loci. METHODS AND RESULTS Using Illumina next-generation sequencing, 54 million reads were collected ...
The development of accurate clinical biomarkers has been challenging in part due to the diversity between patients and diseases. One approach to account for the diversity is to use multiple markers to classify patients, based on the concept that each individual marker contributes information from its respective subclass of patients. Here we present a new strategy for developing biomarker panels...
PURPOSE Local recurrence is the major manifestation of treatment failure in patients with operable laryngeal carcinoma. Established clinicopathological factors cannot sufficiently predict patients that are likely to recur after treatment. Additional tools are therefore required to accurately identify patients at high risk for recurrence. This study attempts to identify and independently validat...
Genomic selection using a realized genomic relationship matrix in a Pinus taeda L. cloned population
Genetic merit can be considered the finite sum of thousands of allelic effects, each physically located at some place on the genome, whose transmission can be traced through molecular markers. Traditionally, best linear unbiased prediction (BLUP) of breeding values relies on average additive genetic covariances (the numerator relationship matrix A) derived from pedigrees to utilize information ...
164 Background: BRCAPRO is a widely used genetic risk prediction model for estimating the carrier probabilities of mutations in BRCA1/2 genes. BRCAPRO has been enhanced to utilize information on molecular markers ER, PR, CK5/6, and CK14. However, no independent validation study on the utility of these markers in risk prediction exists to support using these in actual clinical settings. Further,...
Genomic selection (GS) is becoming an important selection tool in crop breeding. In this study, we compared the ability of different GS models to predict time to young microspore (TYM), a flowering time-related trait, spike grain number under control conditions (SGNC) and spike grain number under osmotic stress conditions (SGNO) in two wheat biparental doubled haploid populations with unrelated...
زمینه وهدف : شواهدی مبنی بر ارتباط بین سطح (hcg.msafp.ue3 inhibina) سرم مادر در سه ماهه دوم حاملگی وپیش بینی زایمان زودرس وجود دارد در این مطالعه با هدف تعیین ارتباط این بیومارکرها با بروز زایمان زودرس انجام شد . روش بررسی : پژوهش حاضر یک مطالعه طولی می باشد که بر روی 700 مادر باردار که در سه ماهه دوم حاملگی جهت انجام تست quad marker screening در فاصله اسفند ماه 1387 تا شهریور1388 مراجعه کرده ...
OBJECTIVES The aim of this study was to assess the association between genetic variants of the insulin receptor substrate (IRS)-1 gene, platelet function, and long-term outcomes in patients with type 2 diabetes mellitus (DM) and stable coronary artery disease while on aspirin and clopidogrel therapy. BACKGROUND The effects of pharmacogenetic determinants on platelet function and cardiovascula...
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