نتایج جستجو برای: mass spectrometry gc ms also
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A robust and complete workflow for metabolic profiling and data mining was described in detail. Three independent and complementary analytical techniques for metabolic profiling were applied: hydrophilic interaction chromatography (HILIC–LC– ESI–MS), reversed-phase liquid chromatography (RP–LC–ESI–MS), and gas chromatography (GC–TOF–MS) all coupled to mass spectrometry (MS). Unsupervised method...
high-performance liquid chromatography with UV detection (HPLC–UV), liquid chromatography coupled with tandem mass spectrometry (LC–MS–MS), and gas chromatography with mass spectrometry (GC–MS) for the characterization and C=C bond localization on the long chain base of sphingolipids in yeast extracts in order to identify the plant sphingolipid desaturases activity. Samples of wild type control...
In the medical examiner setting, comprehensive drug screening is an essential analytical tool in the investigation of cause and manner of death.We have validated non-targeted and targeted screening assays for drugs and metabolites using ultra-performance liquid chromatography (UPLC) interfaced with mass spectrometry (MS) in single and tandem stages. For non-targeted screening by UPLC-MS electro...
Antinociceptive effects, acute toxicity and chemical composition of Vitex agnus-castus essential oil
Objective: Vitex agnus-castus (VAC) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. In this study, the effects of essential oil extracted from Vitex agnus-castus (EOVAC) leaves were investigated in three behavioral models of nociception in adult male Wistar rats. Materi...
Synthetic cathinones are analogue compounds of the plant based stimulant cathinone. Its use, abuse, and related consumption complications have steadily increased in last years. For this reason, there is a need for innovative analytical approaches that enable its rapid screening biological matrices (e.g., oral fluids). The present work proposes new methodology by combining bar adsorptive microex...
Traditional flavor analysis relies on gas chromatography coupled to mass spectrometry (GC-MS) methods. Here we describe an indirect method coupling volatile compound formation to an ARO9-promoter-LacZ reporter gene. The resulting β-galactosidase activity correlated well with headspace solid phase micro extraction (HS/SPME) GC-MS data, particularly with respect to the formation of rose flavor. T...
Studies are described on the phase I and II metabolism and the toxicological analysis of the piperazine-derived designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP) in rat urine using gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). The identified metabolites indicated that TFMPP was extensively metabolized, mainly by hydroxylation of the ...
Different solvent extracts of a red algae, Hypnea flagelliformis,and two brown algae, Cystoseira myrica and Sargassum boveanum, collected from the Persian Gulf coast were subjected to different bioassays including: 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay, antibacterial and antifungal activity by thin layer chromatography (TLC)-bioautography, agar disc diffusion (ADD) ...
Urine has long been a "favored" biofluid among metabolomics researchers. It is sterile, easy-to-obtain in large volumes, largely free from interfering proteins or lipids and chemically complex. However, this chemical complexity has also made urine a particularly difficult substrate to fully understand. As a biological waste material, urine typically contains metabolic breakdown products from a ...
To investigate the utility of comprehensive GC×GC gas chromatography metabolomics in finding varietal markers among volatile compounds non-aromatic red wines, representative samples two most important Croatian monovarietal Plavac mali and Teran, were subjected to analysis by both conventional chromatography–mass spectrometry (GC-MS) two-dimensional with time-of-flight mass (GC×GC-TOF-MS) after ...
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