Li and Li (1) reviewedour article (2),which was published in Diabetes Care and concerned the potential confounding effect of maternal metabolic conditions, particularly maternal diabetes and obesity, on the associationbetweenautism spectrum disorder (ASD) and type 2 diabetes risk. Li and Li (1) mentioned that a growing body of evidence supports the association of maternal diabetes and obesity w...

OBJECTIVES This paper reports secular trends in diabetes in pregnancy in Victoria, Australia and examines the effect of including or excluding women with pre-existing diabetes on gestational diabetes (GDM) prevalence estimates. DESIGN Population-based observational study. SETTING All births in Victoria, Australia between 1999 and 2008 PARTICIPANTS: 634,932 pregnancies resulting in a birth r...

how to cite this article: talebian a, soltani b, sehat m, zahedi a, noorian a, talebian m. incidence and risk factors of neural tube defects in kashan, central iran. iran j child neurol. summer 2015;9(3):50-56. abstract objective neural tube defects (ntds) are the most common congenital defects of central nervous system due to neural tube closure deficit during the third and fourth weeks of ges...

OBJECTIVE Mothers of children at risk for type 1 diabetes report engaging in preventive behaviors. The purpose of this study is to further document these actions in an international, longitudinal sample and examine variables that predict whether mothers engage in these behaviors. RESEARCH DESIGN AND METHODS This study examined an international sample (from Finland, Germany, Sweden, and the U....

OBJECTIVE To assess associations of gestational diabetes, existing diabetes, and glycosuria with adiposity and cardiometabolic risk factors in offspring at adolescence. RESEARCH DESIGN AND METHODS Multivariable regression analyses were conducted in a prospective pregnancy cohort (n = 2,563-4,198 for different outcomes). Obstetric data were abstracted from clinical records. Offspring outcomes ...

OBJECTIVE To assess the relationship between selected maternal and infant characteristics and risk of type 1 diabetes mellitus, specifically characteristics identified from birth records that may pertain to the hygiene or overload hypotheses. DESIGN Population-based case-control study. SETTING Washington State from 1987 to 2005. PARTICIPANTS All children younger than 19 years hospitalized...

Maternal diabetes leads to an adverse in utero environment, but whether maternal diabetes impairs nephrogenesis is unknown. Diabetes was induced with streptozotocin in pregnant Hoxb7-green fluorescence protein mice at embryonic day 13, and the offspring were examined at several time points after birth. Compared with offspring of nondiabetic controls, offspring of diabetic mice had lower body we...

OBJECTIVE We aimed to examine detailed neonatal measurements as predictors of later diabetes in both parents. RESEARCH DESIGN AND METHODS Babies (n = 617) born to nondiabetic parents in Holdsworth Memorial Hospital, Mysore, India, were measured at birth for weight; crown-to-heel length (CHL), crown-to-rump length (CRL), and leg length; skinfolds (triceps and subscapular); and circumferences (...

Maternal diabetes predisposes the growing foetus to non-communicable disease risk later in life. Studies show an increased risk of adiposity/obesity, type-2 diabetes and higher blood pressure in offspring of diabetic mothers. Altered metabolic and neuroendocrine functions, and epigenetic modification of genes involved in these functions are some of the mechanisms proposed for the offspring dise...

Introduction: Gestational diabetes mellitus (GDM) is one of the main public health problems around world. The present study aimed to determine prevalence and risk factors GDM. Objective: To carry out a systematic review through analysis scientific articles in relation predisposing for development Diabetes. Methodology: A studies focused on Diabetes was carried out. bibliographic search Pubmed, ...