Neonatal jaundice is a common disorder worldwide affecting 30-70% of newborn infants. Severe neonatal and its progression to kernicterus leading cause death disability among newborns in poorly-resourced countries. OBJECTIVES: To determine the frequency congenital hypothyroidism new born admitted with at tertiary care hospital Peshawar. METHODOLOGY: Settings: removed for blind review Duration: P...

The reported incidence rate of primary congenital hypothyroidism (CH) has been increasing in the United States over the past 2 decades. We have considered the possibility that the inclusion of cases of transient hypothyroidism has inflated the reported incidence rate of CH. Assessing the effects of cases of transient hypothyroidism on the incidence rate is problematic, because the definitions, ...

In the last two decades, there have been major advances in our understanding of the thyroid physiology during pregnancy , the role of thyroid hormones in fetal development, and the effects of thyroid dysfunction on pregnancy outcomes. The main objective of this special issue was to highlight how these advances have enhanced our knowledge and influenced the clinical practice in the field. The em...

OBJECTIVE To evaluate the costs and benefits of neonatal screening for phenylketonuria (PKU) and congenital hypothyroidism (CH). Neonatal screening for PKU and CH is common throughout the developed world. It represents a model of preventive care in that the screening procedure is simple and intellectual disability is otherwise irreversible. Changes in treatment and care, and in particular the a...

Thyroid hormones (THs) are essential for proper brain development in mammals. TH insufficiency during early development causes structural and functional abnormalities in brain leading to cognitive dysfunction. The specific effects of developmental hypothyroidism on attention have not been well characterized in animal models. The present study was conducted to characterize the effects of develop...

OBJECTIVE Subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy have been associated with an increased risk of gestational diabetes. We aimed to ascertain if these women have a worse metabolic phenotype than euthyroid pregnant women. DESIGN, SUBJECTS AND METHODS We recruited 956 healthy Caucasian women with singleton, non-diabetic pregnancies from routine antenatal clinics. D...

background: the aim of this study was to investigate the relationship between congenital hypothyroidism and several variables using two different adjustment methods. methods: this matched case-control study was conducted in hamadan province, the west of iran, in 2012 enrolling neonates born between 2005 and 2011 and covered by screening program for congenital hypothyroidism. the neonates with t...