We explored the mechanism of the development from sensitivity to resistance to carbapenem in Pseudomonas aeruginosa. Two P. aeruginosa strains were collected during treatment with carbapenem. Strain homology was investigated using pulsed-field gel electrophoresis. Porin oprD2 expression was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The minimum inhibitory ...

Background & Objective: The spread of carbapenem-resistant Pseudomonas aeruginosa is a global concern. Metallo-beta-lactamase (MBL) enzymes cause extensive drug resistance among Gram-negative bacteria. The current study aimed at determining the prevalence of MBL-producing P. aeruginosa in Iran. Methods<...

Hasan, B. 2013. Antimicrobial Resistance and Production of Extended Spectrum BetaLactamases in Enterobacteriaceae from Birds in Bangladesh. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 911. 75 pp. Uppsala. ISBN 978-91-554-8691-4. The dissemination of members of the Enterobacteriaceae family with extended spectrum betalacta...

To the Editor: Pseudomonas putida infections (0.03% of isolates from the culture collection of inpa-tients, SIR Program 2003–2004, www.aam.org.ar) are mainly reported in immunocompromised patients, such as newborns, neutropenic patients, and cancer patients. They are usually susceptible to extended-spectrum cephalosporins, aminoglyco-sides, fluoroquinolones, and car-bapenems. However, isolates ...

A Swedish patient of Indian origin traveled to New Delhi, India, and acquired a urinary tract infection caused by a carbapenem-resistant Klebsiella pneumoniae strain that typed to the sequence type 14 complex. The isolate, Klebsiella pneumoniae 05-506, was shown to possess a metallo-beta-lactamase (MBL) but was negative for previously known MBL genes. Gene libraries and amplification of class 1...

23 We describe the occurrence of blaVIM-2 in 10 carbapenem-resistant Pseudomonas monteilii 24 strains isolated from different clinical samples in our hospital in Northern Spain. All the 25 blaVIM-2-harbouring P. monteilii isolates possessed a class 1 integron, with the cassette array 26 [intI1_blaVIM-2_aac(6’)-Ib_qacE1_sul1]. Our results show the emergence of VIM-227 producing multidrug-resist...

Bacterial metallo-β-lactamases (MBLs) are involved in resistance to β-lactam antibiotics including cephalosporins. Human SNM1A and SNM1B are MBL superfamily exonucleases that play a key role in the repair of DNA interstrand cross-links, which are induced by antitumour chemotherapeutics, and are therefore targets for cancer chemosensitization. We report that cephalosporins are competitive inhibi...