Growth hormone (GH) therapy was approved in 1999 for only GH-deficient Turner syndrome (TS) in Japan. It was subsequently approved for all cases of TS regardless of GH secretory status since 1999. The dose of GH is 1.0 u (0.35 mg)/kg/wk at present, but it was 0.5 u (0.175 mg)/kg/wk before 1999. The adult height in patients with TS on the dose of 0.5 u/kg/wk was studied from the report on of Fou...

Clinical material The incorporation rate of leucine into muscle proteins was sludied in 25 women and 27 men with a mean age of 55 -419 and 52 417 (S.D.) yr, respectively. Cathepsin-D activity in muscle tissue was determined in 28 women, aged 51 417 yr and 13 men, aged 65 410 yr. The patients were admitted to the hospital for operation of uncomplicated gallstone disease or peptic ulcer. Apart fr...

Our aim was to determine if women who regularly perform endurance exercise demonstrate age-related elevations in body mass and adiposity. Ninety-five healthy females were studied: premenopausal ( n = 28; mean ± SE age 30 ± 1 yr) and postmenopausal ( n = 31; 56 ± 1 yr) endurance-trained runners and premenopausal ( n = 17; 29 ± 1 yr) and postmenopausal ( n = 19; 61 ± 1 yr) sedentary controls. In ...

PURPOSE This longitudinal study examined the role of leisure-time physical activity in academic achievement at the end of compulsory basic education and educational attainment in adulthood. METHODS The data were drawn from the ongoing longitudinal Cardiovascular Risk in Young Finns Study, which was combined with register-based data from Statistics Finland. The study consisted of children who ...

    The length-weight relationship, age, growth parameters, sex ratio, mortality and exploitation rate of Salmo trutta fario were determined in Lar dam. The sex ratio (male: female) was 1:1.84 which differed significantly from the expected 1:1. The length-weight regression was (females) and (males) indicating a negative allometric growth for both sexes. Growth parameters were estimated as L∞ = ...

Asbestosis and pleural plaques exhibit unpredictable but progressive development, and there are no markers routinely available to measure their prognosis. Asbestos exposure induces the generation of reactive oxygen species, and 8-isoprostane is involved in experimental asbestos-related lung toxicity. This oxidative stress marker was measured in exhaled breath condensate (EBC) in 92 former asbes...

Silicosis has progressive, but unpredictable development. There are no markers routinely available to measure the activity and prognosis of silicosis. 8-isoprostane, a marker of oxidative stress and leukotrienes B4, C4, D4, and E4 were measured in exhaled breath condensate in patients with silicosis. Sixty subjects were examined, with mean age 66.7+/-2.0 yr and mean exposure to silica 23.6+/-2....

Hyperglycemia is associated with hemodynamic changes in type 1 diabetes (DM), acting in part through renin-angiotensin system activation. Since aging is associated with vascular dysfunction in DM, we hypothesized that acute hemodynamic responses to clamped hyperglycemia and infused ANG II would be exaggerated in older adults compared with a group of adolescent/young adults with type 1 DM. Renal...

OBJECTIVES Aortic arch replacement is associated with increased mortality and morbidity especially in acute type-A aortic dissection. Although hypothermic circulatory arrest with selective antegrade cerebral perfusion has been widely used because of its excellent cerebral protection, its optimal perfusion characteristics are unknown. The present study investigates clinical results obtained afte...

We tested the hypothesis that the age-related decline in maximal aerobic capacity, as measured by maximal oxygen uptake (VO(2 max)), is greater in Hispanic than in Caucasian women. We studied 146 healthy sedentary women aged 20-75 yr: 53 Hispanic (primarily of Mexican descent) and 93 Caucasian (non-Hispanic white). The groups did not differ in mean age, body mass, percent body fat, estimated ph...