The main procedure used by clinicians to determine whether an individual may be at risk of suicidal behaviors is the suicide risk assessment (SRA). The purpose of the SRA is to identify risk and protective factors that then provide the data for the formulation of suicide risk. The suicide risk formulation (SRF) assigns a level of suicide risk that ideally leads to triage and treatment deemed ap...

We use the annealed formulation of complex networks to study the dynamical behavior of disease spreading on both static and adaptive networked systems. This unifying approach relies on the annealed adjacency matrix, representing one network ensemble, and allows to solve the dynamical evolution of the whole network ensemble all at once. Our results accurately reproduce those obtained by extensiv...

Performance-based design is an efficient strategy for assessing and reducing the risk that a construction violates some performance requirement. In this paper, a procedure for performance-based assessment of seismic risk is illustrated with reference to a composite steel-concrete frame structure. Such risk is conventionally evaluated in a simplified formulation, i.e. as the mean annual frequenc...

This paper reports a series of 20 fatalities involving a high-dose, sublingual buprenorphine (BUP) formulation recently marketed in France for the substitutive therapy of opiate addicts. The files were recorded over a 16-month period from five different urban areas in France. All subjects but one were male, aged 14-48 (mean 26.6). BUP and its primary metabolite norbuprenorphine (norBUP) were as...

An effective systems engineering process will provide the framework to enable the complex technical endeavor of railgun system design and development to transition from a set of research projects to a viable acquisition program. The detailed formulation and application of the railgun systems engineering process will be defined by government acquisition agents and the selected private sector con...

An important problem in discrete-event stochastic simulation is the selection of the best system from a finite set of alternatives. There are many techniques for ranking and selection and multiple comparisons discussed in the literature. Most procedures employ classical frequentist approaches, although there has been recent attention to Bayesian methods. In this paper, we compare Bayesian and f...

PURPOSE The present study was conducted to evaluate whether the bioavailability of pregabalin capsules 150 mg manufactured by PT Dexa Medica was equivalent to the reference formulation. METHODS This was a randomized, open-label, two-period, two-sequence, and crossover study under fasting condition, with a 1-week washout period. Plasma concentrations of pregabalin from 20 subjects were determi...

1. The aim was to compare the pharmacokinetics of sitafloxacin from a capsule formulation (dose of 500 mg sitafloxacin) and an intravenous (i.v.) formulation infused over 1 h (dose of 400 mg sitafloxacin) in healthy male and female subjects and to estimate the absolute bioavailability of sitafloxacin from the capsule formulation. 2. Following oral administration, sitafloxacin was rapidly absorb...