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EVI1 is a transcriptional regulator with an important function in haematopoiesis and self-renewal. Aberrant overexpression of EVI1 has been firmly established as one of the most adverse prognostic markers in acute myeloid leukaemia (AML), implying that EVI1 is one of the most aggressive oncogenes in AML. Importantly, a recent report in Leukemia from Konantz et al. suggests that EVI1 might also ...
A 69-year old Caucasian man presented at our Institution in 2011 for a thrombocytosis discovered the past year (platelet count 600–650 × 109/L). His medical history included habitual smoking, and transitory ischemic attack (TIA) that occurred six years before, prompting starting therapy with acetylsalicylic acid (ASA, ie, 100 mg/daily). Physical examination was unremarkable. At referral, blood ...
The Major Histocompatibility Complex (MHC) class II transactivator (CIITA) acts as a master switch to activate expression of the genes required for MHC-II antigenpresentation. During B-cell to plasma cell differentiation, MHC-II expression is actively silenced but the mechanism has been unknown. In plasma cell tumors such as multiple myeloma the repression of MHC-II is associated with the loss ...
In 2016, the European Hematology Association (EHA) published EHA Roadmap for Research1 aiming to highlight achievements in diagnostics and treatment of blood disorders, better inform policy makers other stakeholders about urgent clinical scientific needs priorities field hematology. Each section was coordinated by 1–2 editors who were leading international experts field. 5 years that have follo...
Mastocytosis is a rare myeloid neoplasm characterized by uncontrolled expansion of mast cells, driven in >80% affected individuals acquisition the KIT D816V mutation. To explore hypothesis that inherited variation predisposes to mastocytosis, we performed two-stage genome-wide association study, analyzing 1,035 with positive disease and 17,960 healthy control from five European populations. Aft...
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