PROLOGUE The opioid analgesics represent an important class of agents for the treatment of severe clinical pain, but many effects often limit their usefulness. This manuscript will discuss recent findings in opioid pharmacology, and how medicinal chemists may be able to utilize these findings of novel opioid analgesics with reduced undesired effects. As such, the manuscript serves as an example...

Ligand efficiency as a guide in fragment hit selection and optimization Sabine Schultes, Chris de Graaf, Eric E.J. Haaksma*, Iwan J.P. de Esch, Rob Leurs, Oliver Krämer Boehringer Ingelheim RCV GmbH & Co. KG, Department of Medicinal Chemistry, Dr. Boehringer-Gasse 5-11, Vienna, Austria Leiden/Amsterdam Center for Drug Research (LACDR), Division of Medicinal Chemistry, Department of Pharmacochem...

1Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran 2Research Institute for Nuclear Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran 3Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran 4Department of Medicinal Chemistry, Faculty of Pharma...

current drug design strategies are based on the understanding of the physio-pathology of diseases, biochemical pathways and selection of molecular targets. Modernbiotechnological tools have provided valuable information to facilitate the discovery ofnew drug candidates. Medicinal chemistry has a vital role in a variety of processes aimedat the identification of bioactive substan...

Drug Design and Development Research Center, Tehran University of Medicinal Sciences, Tehran, Iran Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, Tehran, Iran Medicinal and Natural Product Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran *E-mail: [email protected] Received December 9, 2012 DOI 10.1002/jh...

Recent years have seen a dramatic increase in the amount and availability of data in the diverse areas of medicinal chemistry, making it possible to achieve significant advances in fields such as the design, synthesis and biological evaluation of compounds. However, with this data explosion, the storage, management and analysis of available data to extract relevant information has become even a...

a Department of Chemistry, University of Manchester Institute of Science and Technology, Faraday Building, PO Box 88, Manchester, UK M60 1QD b Department of Chemistry, Birkbeck College, University of London, 29 Gordon Square, London, UK WC1H 0PP c Laboratory of Medicinal Chemistry, NIDDK, NIH Bethesda, MD, 20892-0805, USA d Department of Chemistry, Northern Arizona University, Flagstaff, AZ, 86...

Asghar DAVOOD, Eskandar ALIPOUR, Abbas SHAFIEE3,∗ Department of Medicinal Chemistry, Faculty of Pharmacy, Islamic Azad University, Tehran-IRAN Department of Organic Chemistry, Faculty of Chemistry, Islamic Azad University, Tehran-IRAN Department of Chemistry, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14174 IRAN e-mail: ashaf...