Melasma is a common dermatosis that involves changes in normal skin pigmentation, resulting from the hyperactivity of epidermal melanocytes. The consequent hyperpigmentation is mostly induced by ultraviolet radiation. Clinically, melasma is characterized by light to dark brown macules that usually occur on the face, although they can also affect the cervical and anterior thoracic regions and up...

Background: Melasma is a common disorder of acquired hyperpigmentation affecting millions people worldwide, predominantly women. Despite the incidence, there are numerous hyperpigmentary conditions which may clinically resemble melasma. The differential diagnosis melasma therefore wide and prove to be diagnostic challenge for clinicians. This can delay appropriate treatment, adversely impacting...

We reported two cases of clinically typical melasma presenting with unusual histopathologic findings. In one case, the epidermal melanocytes were markedly increased in number and protruded into the dermis, and in the other case, increased epidermal pigmentation as well as dermal melanocytosis were found. We suggested that the various treatment modalities of melasma should be applied depend on i...

Background Melasma is a common disorder of pigmentation, characterized by symmetric brown or brown-gray patches in sun-exposed facial areas. Hydroquinone (HQ) is the most effective agent in melasma treatment; however it has some adverse events (AE) that limit its extensive use. We evaluated the clinical response of aminoacid filaggrin-based antioxidants (AFBA) in Mexican patients with centrofac...

AbstractIntroduction : Melasma is one of the most common hyperpigmentation disorders among womans, patches which commonly found on face especially sunlight exposured area. One factors causing melasma use oral contraceptives cause buildup hormones estrogen and progesterone skin.Objectives Thus, aim study to analyze association between duration contraceptive pills melasma.Methods This used a cros...

The picosecond lasers have shown to effectively treat tattoo pigments that are intractable to previous multiple Q-switched (QS) laser treatments. Therefore we hypothesized that a picosecond laser would show better efficacy with minimal adverse events in the treatment of melasma and post-inflammatory hyperpigmentation (PIH) that are difficult to treat with conventional QS lasers. Two patients wi...

BACKGROUND A 1,927-nm wavelength was recently added to the 1,550-nm erbium-doped fiber laser. This wavelength possesses a higher absorption coefficient for water than the 1,550-nm, conferring greater ability to target epidermal processes such as dyschromia. OBJECTIVE To evaluate the efficacy and safety of a novel 1,927-nm fractional thulium fiber laser in the treatment of melasma. METHODS F...

Background Hypermelanosis includes a diverse group of genetic and acquired skin anomalies that appear as darker, hyperpigmented areas. Melasma, in particular, is a hypermelanotic condition that affects sun-exposed skin in females. Whether this condition is acquired or genetic is still controversial. However, it clearly correlates with exposure to UV light, a genetic predisposition, and hormonal...