PURPOSE Osteoarthritic pain is largely considered to be inflammatory pain. Sensory nerve fibers innervating the knee have been shown to be significantly damaged in rat models of knee osteoarthritis (OA) in which the subchondral bone junction is destroyed, and this induces neuropathic pain (NP). Pregabalin was developed as a pain killer for NP; however, there are no reports on pregabalin use in ...

Term and preterm labor are associated with increased fetal hypothalamic-pituitary-adrenal (HPA) activation and synthesis of prostaglandins (PGs) generated through the increased expression of prostaglandin H synthase-II (PGHS-II) in the placenta. Inhibition of PGHS-II has been advocated as a means of producing uterine tocolysis, but the effects of such treatment on fetal endocrine functions have...

OBJECTIVE To consider the relevance of the duration of a clinical trial in ankylosing spondylitis: long-term (i.e. 1 yr) vs short-term (i.e. 6 weeks) assessment of a non-steroidal anti-inflammatory drug (NSAID)-placebo controlled study. METHODS The design was a prospective, multicentre, double-blind, placebo-controlled study of 6 weeks duration with a 12 months double-blind extension. Study d...

BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) are used routinely to control pain and inflammation after surgery in dogs. Robenacoxib is a new NSAID with high selectivity for the cyclo-oxygenase (COX)-2 isoform of COX. The objective of this study was to evaluate the efficacy and tolerability of robenacoxib for the management of peri-operative pain and inflammation associated with sof...

Objective: This study aimed to find the best SNEDDS meloxicam formula and analyze release kinetics of non-SNEDDS using DDSolver. 
 Methods: Meloxicam was prepared sunflower seed oil, Cremophor RH 40 as a surfactant, polyethylene glycol (PEG) 400 co-surfactant. Results: The obtained subjected in vitro dissolution analyzed shows one selected consists 10% 70% cremophor 40, 20% PEG with 20.5 n...

Objective: To test the potentially toxic urinary tract effects of indomethacin in comparison with a novel COX-2 inhibitor, meloxicam. Method: In vitro experiments were performed using isolated ring segments of sheep ureter mounted in organ-baths. Changes in isometric tension and frequency of rhythmic contractions were assessed in control and lipopolysaccharide (LPS)-treated preparations prior t...

Abstract Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) that frequently administered to animals as an analgesic, antipyretic, and medication. overdose liver damage can occur if taken for extended period of time without first consulting veterinarian. Sukari dates extract neutralize the effects free radicals protect when orally. After being induced by toxic dose meloxicam, purpose th...

In pharmaceutical development, more and drugs are classified as poorly water-soluble or insoluble. Particle size reduction is a common way to fight this trend by improving dissolution rate, transport characteristics bioavailability. Pulsed laser ablation ground-breaking technique of drug particle generation in the nano- micrometer range. Meloxicam, commonly used nonsteroidal anti-inflammatory w...

Objective: To formulate unmodified crystalline meloxicam solid dispersions by the use of surfactants and polymer. This polymeric particulate system is named as meloxicam-loaded surface attached dispersion (MSDs). Methodology: experimental study was conducted at Lab Physical Industrial Pharmacy, Hanyang University, South Korea. The duration this around seven months. first phase (optimization fab...

The purpose of this study was to compare the pharmacokinetics of meloxicam in mature swine after intravenous (i.v.) and oral (p.o.) administration. Six mature sows (mean bodyweight ± standard deviation = 217.3 ± 65.68 kg) were administered an i.v. or p.o. dose of meloxicam at a target dose of 0.5 mg/kg in a cross-over design. Plasma samples collected up to 48 h postadministration were analyzed ...