The patch clamp-liposome technique was used to examine the stretch sensitivity of a model membrane ion channel, gramicidin A, in membrane patches of different bilayer thickness. We found that small changes in phospholipid acyl chain length (i.e., PC-20 to PC-18) can switch gramicidin A from a stretch-activated to a stretch-inactivated channel. The demonstration that subnanometer changes in bila...

Silicone is already widely used in biomedical applications thanks to its outstanding properties. Now additive manufacturing (AM) of silicone can achieve submillimeter details and offered by SpectroPlast AG as a service. AM particularly interesting for designs with complex internal structures such bioreactors or oxygenators where oxygen permeability important. Therefore, the additively manufactu...

How proteins evolve new functionality is an important question in biology; prestin (SLC26A5) is a case in point. Prestin drives outer hair cell somatic motility and amplifies mechanical vibrations in the mammalian cochlea. The motility of mammalian prestin is analogous to piezoelectricity, in which charge transfer is coupled to changes in membrane area occupied by the protein. Intriguingly, non...

Solid-state nuclear track detectors (SSNTDs) in diffusion chambers have been routinely used for long-term measurements of radon gas concentrations. In usual practice, a filter is added across the top of the diffusion chamber to stop the progeny from entering. Thoron can also be deterred from entering the diffusion chamber by using a polyethylene (PE) membrane. However, the thickness of the PE m...

Background:Honey has been shown to accelerate wound healing, which is especially important in the management of patients with full-thickness wounds of skin in dermatologic surgeries. Objective: To evaluate the effects of honey in accelerating healing of full-thickness skin wounds in mice. Methods: Two groups of male NMRI mice (n=12) were subjected to full-thickness skin wounds under general ane...

terms and conditions of current drinking water quality standards, including reducing the maximum arsenic concentration from 50 μgl-1 to 10 μgl-1 and predicted stricter standards in future, reveals the necessity for development of new technologies. this study aimed to prepare and evaluate a new nanocomposite membrane using graphene oxide (go) thin layer to remove arsenic (v) from water. to fabri...

AIMS The aims of this study were to re-assess the histopathology of the disease by introducing more modern measuring techniques and to determine if axial stromal thinning, which is the most apparent change, is related to the other alterations observed. METHODS Recipient keratoconic corneas from 36 patients following corneal transplantation were studied. Haematoxylin and eosin (H&E) and period...

in this research, modification on the ultrafiltration (uf) membrane by synthesis of a thin layer of polyamide selective layer was designed for high performances of forward osmosis (fo) water treatment. two monomers, m-phenylenediamine (mpd) and trimesoyl chloride (tmc) with different concentrations of mpd (2.0% w/v and 1.0% w/v) were reacted with tmc (0.15% w/v) for interfacial polymerization (...

Introduction Bisphosphonates are widely used in metastatic cancer such as prostate and breast cancer, and their nephrotoxic effects have been established previously. In this study we aimed to evaluate both the nephrotoxic effects of zoledronic acid (ZA) and the protective effects of vitamin E (Vit-E) on this process under light and electron microscopy. Material and methods A total of 30 male ...