INTRODUCTION The effect of zoledronic acid, a potent and novel bisphosphonate, on tooth movement and orthodontically induced root resorption in osteoporotic animals systemically treated with zoledronic acid as similarly used in postmenopausal patients has not been elucidated. Therefore, this study was undertaken. METHODS Fifteen 10-week-old female Wistar rats were divided into 3 groups: ovari...

Introduction: The prevalence of periodontitis has reached 42.8% in Indonesia. One contributing factor is Porphyromonas gingivalis. ovarian dysfunction caused by ovariectomy procedures may also cause periodontitis. Post conditions resemble menopause, lowering the production estrogen and progesterone hormones, leaving patients vulnerable to To prevent side effects treatment, herbal ingredients ar...

There is increasing evidence that menopause due to oxidative imbalance will lead to metabolic disorders (1). Menopause also increases food intake and body weight gain and is associated with abnormalities in lipid metabolism (2). More recent experimental studies confirm that ovariectomy cause oxidative stress and cell damage in animals (1,3,4). Steroid hormones, particularly estrogen, are natura...

The classic twin study is sometimes described as "the perfect natural experiment" for the investigation of the aetiology of complex disease, but assumptions of the twin design need to be empirically tested if their results are to be considered unbiased and representative of singleton populations. In this study comparisons of disease and prevalence of lifestyle characteristics have been made bet...

The authors hypothesized that the progesterone component of some hormone replacement therapies in women is detrimental to cognition. A previous study showed that ovariectomy (ovx) in aged rats enhanced spatial working memory and decreased elevated progesterone levels. The current study evaluated whether progesterone administration counteracts these cognitive enhancing effects of ovx. Aged sham ...

Androgens play a number of important physiological roles in the human. In the male, testosterone is required for virilization, normal sexual function, and both stimulation and maintenance of bone and muscle mass. Epidemiological studies have shown a progressive decline in testosterone levels with ageing in men. The clinical significance of this decline is still unclear, and there is controversy...

The increase of heart failure prevalence on menopausal women was correlated with the decrease of estrogen level. The aim of this study is to investigate the effects of ceplukan leaf (Physalis minima L.), which contains phytoestrogen physalin and withanolides, on ventricular TNF-α level and fibrosis in ovariectomized rats. Wistar rats were divided into six groups (control (-); OVX 5: 5-week ovar...

Animal models of menopause have been used to further define the cognitive processes that respond to hormone therapy and to investigate parameters that may influence the cognitive effects of estrogen. Many investigations in animals have focused on memory; however, the effects of hormone therapy on executive function and attention processes have not been well studied. Thus, the purpose of this se...

OBJECTIVE The elevated body weight in post-menopausal state attributes to the reduced estrogen levels which is alleviated by resveratrol (RES) but its role in control rats is not well understood. The main objective of the study was to explore the effects of RES on the body weight of ovariectomized (OVX) female rats with controls and to relate their biochemical parameters. METHODS Female Wista...

With age, there is a decline in both the quantity and quality of the pool of follicles and oocytes. Linear extrapolation of follicular depletion in women with regular menses predicts that, by 50 years of age, each ovary would contain 2500 to 4000 primordial follicles. Because the menopausal ovary is largely devoid of follicles, follicular depletion apparently accelerates in the last decade of r...