Specialism is widespread in nature, generating and maintaining diversity, but recent work has demonstrated that generalists can be equally fit as specialists in some shared environments. This no-cost generalism challenges the maxim that 'the jack of all trades is the master of none', and requires evolutionary genetic mechanisms explaining the existence of specialism and no-cost generalism, and ...

This paper explores the cumulative sustainable supply chain (SC) capabilities and their effects on supply chain performance, including economic, environmental, and social performance. Using empirical analyses with data from 198 smalland medium-sized suppliers in Korea, this paper provides evidence about the cumulative sustainable SC capabilities, indicating that economic, social, and environmen...

The finite derived set property asserts that any infinite subset of a space has an infinite subset with only finitely many accumulation points. Among other things, we study this property in the case of a function space with the topology of pointwise convergence. 2000 AMS Classification: 54A25, 54A35, 54D55.

The restrictive assumptions associated with purely genetic and purely ecological mechanisms suggest that neither of the two forces, in isolation, can offer a general explanation for the evolutionary maintenance of sex. Consequently, attention has turned to pluralistic models (i.e. models that apply both ecological and genetic mechanisms). Existing research has shown that combining mutation accu...

Andrew Heathcote ([email protected]) School of Medicine, The University of Tasmania Social Sciences Building, Sandy Bay, 7005, Tasmania, Australia Brandon Turner ([email protected]) Department of Psychology, The Ohio State University, Columbus, OH 43227 USA Scott D. Brown ([email protected]) School of Psychology, The University of Newcastle, Psychology Building, Universit...

Globoid cell leukodystrophy (GLD; Krabbe disease), is a rare heritable metabolic disorder in humans, dogs, mutant twitcher mice, and rhesus monkeys that is caused by a deficiency in the lysosomal enzyme galactocerebrosidase (GALC). GALC deficiency results in the accumulation of psychosine, which is toxic to oligodendrocytes and Schwann cells of the central and peripheral nervous systems. Clinic...

The genetically-linked deficiency in the activity of hepatic phenylalanine 4-hydroxylase (EC 1.14.16.1) leads to a marked accumulation of L-phenylalanine (L-Phe) and some of its metabolic products, namely phenylpyruvate, phenyl-lactate and o-hydroxyphenylacetate, in the blood and tissues of patients with uncontrolled phenylketonuria (PKU). In order to explain the biochemical mechanisms by which...

Woodhouse-Sakati syndrome (WSS) is an infrequent autosomal recessive condition characterized by progressive extrapyramidal signs, mental retardation, hypogonadism, alopecia, and diabetes mellitus. This syndrome belongs to a heterogeneous group of inherited neurodegenerative disorders characterized iron accumulation in the brain, and it is caused by mutations of the C2orf37 gene. We report the f...

BACKGROUND AND OBJECTIVE In a security ward we assessed the diagnostic contribution of single photon scintigraphy [SPECT] in our diagnostic pathway for patients with serious mental disease and a history of violence. METHODS Twenty patients were examined between 2012 and 2015 and the findings compared to those in nine patients with the same diagnosis, but no history of violence. RESULTS All ...

The tree-drawing problem is to produce a `tidy' mapping of elements of a tree to points in the plane. In this paper, we derive an eecient algorithm for producing tidy drawings of trees. The speciication, the starting point for the derivations, consists of a collection of intuitively appealing criteria satissed by tidy drawings. The derivation shows constructively that these criteria completely ...