Background: During the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. This is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. Arginase competes with inducible nitric oxide synthase for a common substrate L-arginine. Objective: To investigate whethe...

Mitochondrial ATP synthase is the major producer of in respiratory cells and maintains mitochondrial membrane potential ΔΨm glycolytic cells. For these purposes, it works forward (ATP synthesis) or reverse mode hydrolysis). These two modes are not necessarily antagonistic. We provide evidence that both functional types can be found within same mitochondria. combined inhibitor studies with high-...

Relevance. The increase in the number of severe brain injuries due to stroke and traumatic injury determines need study develop effective strategies for neuroprotection. article highlights new mechanisms neuroprotective action inhalation anesthetic xenon based on data our own experimental studies. Aim study. To assess effect anesthesia with at a concentration 0.5 MAC (minimum alveolar concentra...

Riboflavin synthase is an important enzyme catalyzing the last step of riboflavin biosynthesis in microorganisms. Due to absolute dependency microbes this biosynthetic pathway coupled with its nonexistence humans, (RiS) considered as a prospective drug target. The for study was derived from Leptospira kmetyi, pathogenic bacterium locally isolated Malaysia. Leptospirosis, infectious disease caus...

Aim: This study aimed to investigate the effects of relaxin (RLX) on hypertensive disorders pregnancy (HDP) and fetal growth restriction (FGR) using a nitric oxide synthase (NOS) inhibitor-induced HDP murine model.

Abstract Background The oxidative phosphorylation (OXPHOS) that takes place in the mitochondria produces chemical energy form of ATP, main source heart. Proper mitochondrial function determines contractility Changes myocardial ATP levels are often associated with cardiovascular disease. However, dysfunction remains an unmet therapeutic challenge. F1FO ATP-synthase protein complex catalyses last...

Background: The widespread use of specialized food products, including plant-based dietary supplements, is determined by a rich variety biologically active constituents. However, some plants containing such bioactive compounds as pulegone, menthofuran, estragole, methyleugenol, safrole, and thujone may cause adverse health effects. Objective: To review recent domestic international scientific p...