G, et al. Routine use of real-time quantitative PCR for laboratory diagnosis of Epstein-Barr virus infection. SG, et al. Is TTF1 a good immunohistochemical marker to distinguish primary from metastatic lung adenocarcinomas? The role of Epstein-Barr virus infection and and infective copy number in pulmonary carcinogenesis. Detection of the Epstein-Barr virus in primary adenocarinoma of the lung ...

Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin neoplasia. The merkel cell polyomavirus (MCPyV), a double-stranded DNA tumor virus was discovered in 2008. It is found in approximately 80% of human MCC and is suspected to play a role in MCC development [1]. Both, small tumor and the aminoterminal moiety of the large tumor antigen, were found to be expressed in MCPyV-posi...

Small cell carcinoma (SmCC) is a distinct clinicopathological entity first described in the lung. It represents approximately 15% of all bronchogenic carcinoma. Extrapulmonary small cell carcinoma (EPSmCC) morphologically indistinguishable from small cell lung cancer (SCLC) was first reported in 1930. Since its first description, EPSmCC has been reported in virtually all anatomical sites, inclu...

Merkel cell carcinoma is a rare but aggressive neuroendocrine tumor of the skin with high propensity for local, regional and distant soft tissue metastasis not only at initial presentation but also after timely and satisfactory wide-margin surgery. Bone metastases account for 10% of all cases and have been reported involving the calvarium, facial bones and spine related to the head and neck pre...

BACKGROUND Merkel cell carcinoma is an aggressive neuroendocrine cell carcinoma arising in the epidermis of patients aged >60 years. This lesion is found in sun-exposed areas and presents as a small violet raised nodule. It is usually painless and rapidly growing. Although its clinical presentation and characteristic histology are usually sufficient, immunohistochemical features are helpful in ...

Merkel cell carcinoma is an aggressive neuroendocrine skin cancer that usually affects elderly patients. Despite being uncommon, incidence has been steadily increasing over the last two decades, likely due to increased awareness, better diagnostic methods and aging of the population. It is currently one of the most lethal cutaneous malignancies, with a five-year overall survival of approximatel...

Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumour that is locally aggressive. In most cases the primary treatment is local surgical excision; however, there is a high incidence recurrence both local and distant. Cerebral metastases from Merkel cell carcinoma are extremely uncommon with only 12 cases published in the literature. This case is particularly unusual in that, no...

Merkel cell carcinoma is an extremely rare neuroendocrine neoplasm of the external auditory canal (EAC) skin, which requires wide excision and adjuvant radiation due to a high recurrence rate. In this report, we describe case arising from EAC was successfully treated with endoscopic excision. A 32-years-old female patient history papillary thyroid cancer diagnosed tumor incidentally. There eryt...

of the fi rst diagnosed case (in Spain) in a human with aseptic meningitis.lence of West Nile virus neutralizing an-tibodies in colonial aquatic birds in southern Spain. and performance testing of quantitative real time PCR assays for infl uenza A and B viral load measurement. Detection and differentiation of pathoge-nicity of avian paramyxovirus serotype 1 from fi eld cases using one-step reve...