BACKGROUND Cerebral infarcts distal to carotid stenoses are thought to be caused by emboli from inflamed, destabilized plaques. We hypothesized that microembolic signals (MES) on transcranial Doppler will be associated with carotid plaque inflammation on (18)F fluorodeoxyglucose positron-emission tomography (FDG PET) in recently symptomatic patients. METHODS AND RESULTS Sixteen patients prese...

We conducted autosomal genome scans to map loci for metabolic syndrome (MES) and related traits in the Hong Kong Family Diabetes Study. We selected 55 families with 137 affected members (121 affected relative pairs) for nonparametric linkage analysis on MES. We also selected 179 families with 897 members (2,127 relative pairs) for variance component-based linkage analyses on seven MES-related t...

Methylation of histone H3K36 in higher eukaryotes is mediated by multiple methyltransferases. Set2-related H3K36 methyltransferases are targeted to genes by association with RNA Polymerase II and are involved in preventing aberrant transcription initiation within the body of genes. The targeting and roles of the NSD family of mammalian H3K36 methyltransferases, known to be involved in human dev...

AIM This pilot study aimed to evaluate the individual features of the metabolic syndrome (MeS) and its frequency in Qatari schoolchildren aged 6-12 years. BACKGROUND MeS has a strong future risk for development of diabetes and cardiovascular diseases. Childhood obesity is increasing the likelihood of MeS in children. METHODS The associated features of MeS were assessed in 67 children. They ...

Knowledge used by maintenance engineers (MEs) in resolving a software maintenance (SM) activity is crucial for any organization. Given this criticality of knowledge, attention must be paid to the effective management of knowledge. One of the major challenges to this is to be able to capture the knowledge and thought processes used by MEs and disseminate it to other MEs. Our paper provides a pra...

The present article attempts to investigate the validity of the Comanor–Wilson Minimum Efficient Size (MES) measure. The basic assumption is that firms that have exhausted scale economies are in non-increasing returns to scale. The same firms are also assumed to have a size greater than MES estimated on sales (total turnover), employment or fixed assets. Data Envelopment Analysis (DEA) is used,...

The Polycomb repression complex 2 (PRC2) methylates histone H3 lysine 27 at target genes to modify gene expression, and this mark is recognized by PRC1, which ubiquitylates histone H2A. In Caenorhabditis elegans, a complex of the MES-2, MES-3 and MES-6 proteins is functionally analogous to the PRC2 complex, but the functional analog of PRC1, and indeed whether C. elegans has such a complex, has...

The electronic structures of two uranium compounds supported by redox-active α-diimine ligands, ((Mes)DAB(Me))(2)U(THF) (1) and Cp(2)U((Mes)DAB(Me)) (2) ((Mes)DAB(Me) = [ArN═C(Me)C(Me)═NAr]; Ar = 2,4,6-trimethylphenyl (Mes)), have been investigated using both density functional theory and multiconfigurational self-consistent field methods. Results from these studies have established that both u...

Reaction of dimesityliron(II) (Fe2(mes)4) with the N-heterocyclic carbenes 1,3-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene (IPr) and 1,3-bis(2,6-dimethylphenyl)hexahydropyrimidin-2-ylidene (6-Xyl) afforded the novel trigonal planar complexes [Fe(IPr)(mes)2] (1) and [Fe(6-Xyl)(mes)2] (2), respectively. Both species were structurally characterized by single crystal X-ray diffraction and display...