نتایج جستجو برای: mesenchymal transition

تعداد نتایج: 307477  

Journal: :Head & neck 2017
Yoshifumi Matsumoto Hiroyuki Sakurai Yasunao Kogashiwa Toru Kimura Yuma Matsumoto Takashi Shionome Masatake Asano Koichiro Saito Naoyuki Kohno

BACKGROUND Despite improved survival by the addition of a monoclonal antibody against epidermal growth factor receptor (EGFR), cetuximab, to chemotherapy or radiotherapy for squamous cell carcinoma of the head and neck (SCCHN), cetuximab by itself is not a potent antiproliferative agent against SCCHN. We aimed to elucidate working mechanism of cetuximab in SCCHN. METHODS The effect of cetuxim...

Journal: :Frontiers in Molecular Medicine 2023

Malignant melanoma is the most lethal form of skin cancer. Y-box binding protein 1 (YB-1) plays a prominent role in mediating metastatic behavior by promoting epithelial-to-mesenchymal transition (EMT). Migratory cells exhibit two major migration modes: elongated mesenchymal or rounded amoeboid. Using A375 cell line and YB-1 knock-out model, we aimed to elucidate biochemical biomechanical chang...

Journal: :Cellular and Molecular Life Sciences 2016

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