BACKGROUND Stem cell-enriched fat grafting has been proposed as a potential therapy for reconstructive, restorative, or enhancement-related procedures of the breast. Its role in postoncologic breast reconstruction is still emerging, with concerns about safety. The authors investigated the dose-dependent interaction between human adipose-derived mesenchymal stromal cells (AD-MSCs) and human brea...

BACKGROUND AND OBJECTIVES Epithelial to mesenchymal transition (EMT) is considered to play an important role in cancer invasion. Tumor budding is a prognostic factor in esophageal squamous cell carcinoma (ESCC). The aim of this study was to explore the correlation between EMT and tumor budding. METHODS Surgical specimens from 78 cases of ESCC resected without preoperative treatment between 20...

Abstract Background Tumor cell extensions called tumor microtubes (TMs) in glioma resemble neurites during neurodevelopment and connect cells to a network that has considerable relevance for progression therapy resistance. The determination of interconnectivity individual tumors been challenging the impact connectivity on patient survival remained unresolved so far. Material Methods A signature...

Although the majority of mesenchymal lesions of the gastrointestinal tract are neoplastic in nature, but nonneoplastic reactive processes may also involve the gastrointestinal tract and mesentery. Some more aggressive neoplasms located in same area, such as fibromatosis or gastrointestinal stromal  tumors  may  be  cause  of  diagnostic  confusion.  Reactive  nodular  fibrous  pseudo  tumor (RN...

Chondrosarcoma is a mesenchymal tumor composed of tumor cells producing cartilage. It is more common in older age and often affects the axial skeleton. We report a rare case of chondrosarcoma mimicking a sellar and suprasellar mass with parasellar extension. A 40 yr woman presented with decreasing visual acuity and headache. Magnetic resonance (MR) image revealed a cystic sellar and suprasellar...

Sinonasal teratocarcinosarcoma (SNTCS) is a rare tumor characterized by mixture architecture of epithelial and mesenchymal components. SNTCS is a highly malignant tumor displaying progressive and aggressive growth with poor prognosis. Only about 40% of all patients survive after five years. It seems the combination of surgery and radiotherapy currently is the most effective treatment. In this r...

Liposarcoma is the most common malignant soft tissue tumor in adults. Extremities and retroperitoneum are sites of involvement liposarcoma. gastrointestinal tract rare colon an extremely uncommon site. Mesenchymal tumors bowel mainly represented by stromal (GIST). A sixty-one-year-old male patient presented with abdominal pain distension. Contrast-enhanced computerized tomography (CECT) showed ...

Forced overexpression and/or downregulation of proteins regulating epithelial-to-mesenchymal transition (EMT) has been reported to alter metastasis by changing migration and stem cell capacity of tumor cells. However, these manipulations artificially keep cells in fixed states, while in vivo cells may adapt transient and reversible states. Here, we have tested the existence and role of epitheli...