BACKGROUND Acinetobacter baumannii is an opportunistic microorganism with an increasing role in nosocomial outbreaks. For the last 2 decades, a growing number of carbapenem-resistant A. baumannii strains have been identified, including the metallo-beta-lactamases (MBLs) producers. The study aimed to investigate the genetic relatedness of, and MBLs production among, a collection of A. baumannii ...

Metallo-beta-lactamases are zinc enzymes able to hydrolyze the four-membered ring of beta-lactam antibiotics, representing one of the latest generations of beta-lactamases. These enzymes belong to the zinc metallo-hydrolase family of the beta-lactamase fold. Enzymes belonging to this family have a bimetallic active site whose structure varies among different members by point substitutions of th...

background & objectives: pseudomonas aeruginosais one of the most important causes of nosocomial infections particularly in immunodeficient patients. several antibiotics such as betalactams, aminoglycosides and quinolones are used for the treatment of infections caused by this organism, but the prevalence of multidrug resistant strains has been reported frequently. beta lactamase production is ...

Beta-lactam antibiotics are among the most important drugs used to fight bacterial infection. Overuse and misuse of beta-lactam antibiotics has caused the evolution of resistance mechanisms, allowing pathogenic bacteria to survive antibiotic treatment. The major source of resistance to beta-lactam antibiotics occurs through production of enzymes called beta-lactamases capable of catalyzing hydr...

BACKGROUND Escherichia coli strains mainly fall into four phylogenetic groups (A, B1, B2, and D) and that virulent extra-intestinal strains mainly belong to groups B2 and D. AIM The aim was to determine the association between phylogenetic groups of E. coli causing extraintestinal infections (ExPEC) regarding the site of infection, expression of virulence factors, antimicrobial resistance pat...

background treatment of infectious diseases is becoming more challenging with each passing year. this is especially true for infections caused by pseudomonas aeruginosa, an opportunistic pathogen with the ability to rapidly develop resistance to multiple classes of antibiotics. objectives this study was conducted to determine the prevalence of metallo-β-lactamase (mbl)–producing strains among m...

conclusions biofilm formation (both strong and weak) strongly correlated with psla gene carriage. biofilm formation also correlated with mbl and ampc β-lactamase production. more importantly, multiple-β-lactamase phenotype was associated with formation of strong biofilms. results biofilm formation was observed in 43.5% of the isolates, of which 66.7% produced strong and 33.3% formed weak biofil...

background and objective: metallo-beta-lactamase (mbl)-mediated resistance is an emerging threat in hospital isolates of pseudomonas aeruginosa. there is not enough information from iran regarding the prevalence and the screening methods for such enzymes. the present study was undertaken to detect metallo betalactamase in strains of p. aeruginosa isolated from burned patientusingphenotypic meth...

Prompt detection of metallo-beta-lactamase (MBL) producing isolates is necessary to prevent their dissemination. Frequency of MBLs producing strains among multidrug resistant (MDR) Acinetobacter species and Pseudomonas aeruginosa was evaluated in critical care patients using imipenem-EDTA disk method. One hundred MDR Acinetobacter spp. and 42 Pseudomonas aeruginosa were checked for MBL producti...

Background & Aims: One of the main causes of nosocomial infection is pseudomonas aeruginosa and carbapenems is one of the most important classes of antibiotics used in the treatment of infections caused by this bacteria. Metallo-beta-lactamase (MBL) production is one of the most important mechanisms of resistance to carbapenems and their increased prevalence is a serious threat to treatment of ...