That flavonoids inhibit xanthine oxidase from cow milk was confirmed by measuring oxygen consumption with an oxygen electrode. In contrast, flavonoids did not inhibit glucose oxidase, another oxygen consuming enzyme. Among the flavonoids tested, quercetin, kaempferol, myricetin, chrysin, quercitrin, and morin were potent inhibitors of xanthine oxidase; their inhibition rates (%) were 80, 70, 69...

Six citrus flavonoids were tested for antineoplastic activity. The hamster cheek pouch model was utilized, and the solutions of the flavonoids (2.0-2.5%) and the solution of the carcinogen, 7,12-dimethylbenz[a]anthracene (0.5%), were applied topically to the pouches. The pouches of the positive controls were treated with the solvent used to dissolve the flavonoids and the solution of the carcin...

The present study was designed to evaluate the effects of flavonoids luteolin (L) and quercetin + luteolin (Q + L) in combination with commonly used antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates and S. aureus (ATCC 43300). Minimum inhibitory concentrations (MICs) of L and Q + L, as well as the MICs of flavonoids in combination with antibiotics...

background free radicals are known as atoms and molecules which are highly reactive with the body’s single-electrons, and may cause irrecoverable damages to the macromolecules of organisms. systems to deal with damages caused by free radicals are known as “antioxidant immune systems”. flavonoids and polyphenolic compounds are from non-enzymatic antioxidants which many nutritional compounds cont...

givotia rottleriformis has been used in the indigenous systems of medicine for the treatment of inflammatory diseases like rheumatism and psoriasis. in order to evaluate this information, antipsoriatic activity of three flavonoids isolated from the ethanol extract of the bark of givotia rottleriformis were investigated using in-vitro and in-vivo model, namely rutin (i), luteolin-7-o-β-d-glucuro...

• Numerous studies have reported the protective cardiovascular effects of polyphenolic antioxidants. It is estimated that flavonoids contribute approximately two-thirds of all the polyphenols ingested, whereas phenolic acids contribute the remaining one third. Red wine is a very rich source of flavonoids, particularly the class called flavanols. Other important sources of flavonoids are apples,...

Diets high in flavonoids have long been associated with nutritional recommendations, a healthy lifestyle, and the prevention of chronic diseases. However, identification of specific beneficial effects from specific flavonoids and flavonoid-rich foods has been a challenging area, probably due to a nonessential or conditional role for flavonoids in human nutrition. Nonetheless, recent efforts in ...

Radix Puerariae is the dried root of Pueraria lobata (Willd.) Ohwi, which releases a variety of isoflavones. The objective is to investigate the extraction process of total flavonoids in Radix Puerariae and to examine their effects on blood glucose MDA in alloxan-diabetic mice. Solvent extraction and column chromatographic isolation were used to extract the total flavonoids in Radix Puerariae, ...

The ability of the flavonoids genistein, apigenin, kaempferol, and quercetin to activate cystic fibrosis transmembrane conductance regulator-mediated Cl currents in human airway epithelium was investigated. We used the patch-clamp technique on single Calu-3 cells, transepithelial measurements in Calu-3 monolayers, and in vivo measurements of nasal potential difference. All flavonoids stimulated...

Flavonoids are pigmentary compounds existing widely in plants. We have reported that quercetin (3, 3', 4', 5, 7-pentahydroxylflavone), one of the typical flavonoids, strongly promotes melanogenesis by melanocytes. Meanwhile, there are 8000 or more flavonoids having a chemical structure different from each other in the natural world. Their distinctive chemical properties suggest that they may be...