BACKGROUND Steroid injections are used in idiopathic carpal tunnel syndrome (CTS), but evidence of efficacy beyond 1 month is lacking. OBJECTIVE To assess the efficacy of local methylprednisolone injections in CTS. DESIGN Randomized, placebo-controlled trial. (ClinicalTrials.gov: NCT00806871). SETTING Regional referral orthopedic department in Sweden. PATIENTS Patients aged 18 to 70 yea...

statement of problem: glucocorticoid-induced osteoporosis is characterized by a decrease in osteoblast numbers and a marked impairment of new bone formation. purpose: the ain of present study was to evaluate the effect of methylprednisolone acetate on bone metabolism and bone mineral density in rats. materials and methods: eighteen male sprague dawley rats (8 weeks old, weighting 180 gm) were r...

BACKGROUND Seroma formation, the most prevalent postoperative complication after mastectomy, is an inflammatory process that is potentially preventable via local steroid administration. This study investigated the effect of local steroid administration on seroma formation. METHODS This was a double-blind randomized placebo-controlled intervention study of a single dose of 80 mg methylpredniso...

OBJECTIVE To compare the efficacy of long-acting IM methylprednisolone to tapering oral methylprednisolone in adult asthmatic patients discharged from the emergency department (ED). METHODS Randomized, double-blind, placebo-controlled trial of a single IM dose of 160 mg depot methylprednisolone vs 8-day tapering of a total dose of 160 mg oral methylprednisolone in adult asthmatic patients (ag...

Acute hepatic and renal failure rarely occur simultaneously. Our case is to report the effect of early methylprednisolone treatment on these patients. We describe the clinical presentation, course, and outcome of a 61-yearold man patient with hyperthyroidism, who was treated with methimazole but developed an allergic reaction to the antithyroid drugs that led to pruritus and cholestatic hepatic...

BACKGROUND Post herpetic neuralgia is a chronic neuropathic pain syndrome which remains one of the most difficult pain disorders to treat. Epidural injection of methylprednisolone with or without local anesthetic provides relief for neuralgia for a short duration only. Recent studies have shown a promising anti nociceptive effect for intrathecal midazolam, a water soluble benzodiazepine, due to...

BACKGROUND Although epidural corticosteroid injections are commonly used for sciatica, their efficacy has not been established. METHODS In a randomized, double-blind trial, we administered up to three epidural injections of methylprednisolone acetate (80 mg in 8 ml of isotonic saline) or isotonic saline (1 ml) to 158 patients with sciatica due to a herniated nucleus pulposus. All patients had...

BACKGROUND Persistent acute respiratory distress syndrome (ARDS) is characterized by excessive fibroproliferation, ongoing inflammation, prolonged mechanical ventilation, and a substantial risk of death. Because previous reports suggested that corticosteroids may improve survival, we performed a multicenter, randomized controlled trial of corticosteroids in patients with persistent ARDS. METH...

Treponema pallidum cultivation is facilitated by substitution of methylprednisolone acetate suspension for hydrocortisone administration during rabbit testicular infection. Methylprednisolone suspension reduces testicular mononuclear cell infiltration and should benefit future studies of virulent T. pallidum.

Methylprednisolone induced arrhythmias, especially bradycardia, are well known. Most of the available reports suggest the occurrence of these arrhythmias with high dose intravenous therapy. We, hereby report a case of low dose methylprednisolone induced bradycardia.