optic neuritis an inflammatory disorder of the optic nerve inflammation is usually in young’s with symptoms of eye pain and vision loss that occurs is a common symptom of ms. optic neuritis is one of the first symptoms of ms that observable into disorders in white matter of cerebral cortex. the risk of ms in patients with optic neuritis during 2 years 20% in 15 years, 45-80% is calculated. ‏in ...

The specific pathogenesis of steroid‑induced osteonecrosis (ON) is yet to be elucidated and until recently effective prophylactic therapies have not been available. The local renin‑angiotensin system (RAS) exists in the bone and has an important role in local bone regulation. However, to the best of our knowledge, the interrelation between local bone RAS and steroid‑induced ON is yet to be inve...

BACKGROUND Shoulder pain from inflammatory arthritis and/or degenerative disease is a common cause of morbidity in the community. It is difficult to treat and there are limited data on the efficacy of most interventions. Suprascapular nerve block has shown promise in limited trials in reducing shoulder pain. There have been no large randomised placebo controlled trials examining the efficacy of...

OBJECTIVE Satisfactory results have been seen with epidural steroid injections (ESI) in patients with herniated disks (HD), but the role in lumbar spinal stenosis (LSS) has been less investigated. We compared long-term effects of ESI in HD and LSS patients. METHODS In a prospective, single-blind uncontrolled study, 60 patients with radicular pain due to HD (n = 32) or LSS (n = 28) were enroll...

Methylprednisolone pharmacokinetics and its directly suppressive effects on plasma cortisol, blood histamine (basophils), and circulating helper T cells were evaluated in six obese (at least 35% above ideal body weight) men and six nonobese male volunteers. Methylprednisolone doses of 0.6 mg/kg total body weight were administered as the 21-succinate sodium salt. Absolute clearance (in liters pe...

Epiphyseal involvement of a unicameral bone cyst (UBC) is rare. This anatomic setting represents a distinct clinical and radiographic entity. This study reports a new case and analyzes the clinical and biological behavior of seven additional UBCs with epiphyseal involvement from the literature. We report the first successful treatment of this variant with methylprednisolone acetate. The average...

Acutely ill asthmatic patients treated in the usual fashion in an emergency room setting and discharged within six hours were studied to determine whether therapy with a single injection of a repository corticosteroid (methylprednisolone sodium acetate) could be as effective as a tapering course of oral corticosteroids in decreasing asthma symptomatology and relapse within seven days. Seventeen...

we are presenting a case illustrating atrial fibrillation (af) following the use of methylprednisolone in a patient with pelvic and femur fracture. a 48- year- old man with no significant past medical history, was admitted to the emergency department after injury in a car accident. he suffered a multiple bone fracture with chief complaints of pain and shortness of breath. he was transferred to ...

This study was undertaken to determine whether glucocorticosteroids promote the secretion of lubricating surfactant, i.e. surface-active phospholipid (SAPL), into the joint. A standard clinical dose (100 mg) of methylprednisolone acetate (MPA) in 2.5 ml of saline was injected into the load-bearing right radiocarpal joint of five horses and 2.5 ml of saline injected into each of the contralatera...

OBJECTIVES To verify whether changes in bone mass induced by glucocorticoid and bisphosphonate can be detected by digital subtraction radiography of lateral X-rays in female rat mandibles. METHODS 36 Rattus norvegicus (Wistar) females were randomly allocated to three groups: Group 1, control (n = 12); Group 2, induced osteopaenia (n = 12); and Group 3, induced osteopaenia plus risedronate (n ...