The mechanisms of the photochemical isomerization reactions were investigated theoretically using a model system of 2-cyanopyrrole and 2-cyano-5-methylpyrrole with the CASSCF (eight-electron/seven-orbital active space) and MP2-CAS methods and the 6-311(d,p) basis set. The structures of the conical intersections, which play a decisive role in such phototranspositions, were obtained. The intermed...

N-Methylpyrrole (Py)-N-methylimidazole (Im) polyamides are small organic molecules that can recognize predetermined DNA sequences with high sequence specificity. As many eukaryotic promoter regions contain highly GC-rich sequences, it is valuable to synthesize and characterize Py-Im polyamides that recognize GC-rich motifs. In this study, we synthesized four hairpin Py-Im polyamides 1-4, which ...

The dynamics of N-methylpyrrole following excitation at wavelengths in the range 241.5-217.0 nm were studied using a combination of time-resolved photoelectron spectroscopy (TRPES), ab initio quantum dynamics calculations using the multi-layer multi-configurational time-dependent Hartree method, as well as high-level photoionization cross section calculations. Excitation at 241.5 and 236.2 nm r...

In this research, electrodeposition procedure was utilized for the synthesis of a new composite polymer: N-methylpyrrole–Triton–X100/N, N,N-diethylaniline (NMPY-TRX100/NNDEA) used as coating on carbon steel type OL 37 electrode corrosion protection. The surfactant Triton–X100, dopant ion throughout process electropolymerization, had significant impact protection by impeding penetration corrosiv...

The aminocoumarin antibiotic clorobiocin contains a 5-methylpyrrole-2-carboxylic acid unit, attached via an ester bond to the 3-OH group of the deoxysugar moiety. To investigate candidate genes responsible for the formation of this ester bond, a gene inactivation experiment was carried out in the clorobiocin producer Streptomyces roseochromogenes var. oscitans DS 12.976. An in-frame deletion wa...