We propose that word recognition in continuous speech is subject to constraints on what may constitute a viable word of the language. This Possible-Word Constraint (PWC) reduces activation of candidate words if their recognition would imply word status for adjacent input which could not be a word--for instance, a single consonant. In two word-spotting experiments, listeners found it much harder...

Three word-spotting experiments assessed the role of syllable onsets and offsets in lexical segmentation. Participants detected CVC words embedded initially or finally in bisyllabic nonwords with aligned (CVC.CVC) or misaligned (CV.CCVC) syllabic structure. A misalignment between word and syllable onsets (Experiment 1) produced a greater perceptual cost than a misalignment between word and syll...

PERSPECTIVES 476 Tolerance for Predatory Wildlife A. Treves and J. Bruskotter 477 Dysfunctional Mechanosensing in Aneurysms J. D. Humphrey et al. 479 Forming Terrestrial Planets J. Chambers 480 A New Wrap for Neuronal Activity? M. E. Bechler and C. ffrench-Constant >> Research Article p. 487 482 Assembly and Disassembly of Ferrocene-Based Nanotubes Z. M. Hudson and I. Manners >> Report p. 499 4...

Exercise can be used as a mood regulator but, in the eating disorder literature, exercise has sometimes been found to be compulsive, detrimental to physical health, and regarded as one maladaptive strategy used to regulate emotions. This study examined longitudinal associations between emotion regulation styles and this compulsive exercise in 572 adolescents who completed measures of compulsive...

One challenge for theories of word recognition is to determine how the listener recovers the intended lexical segmentation in continuous speech. We argue that syllable structure provides one source of constraint on lexical segmentation and more precisely, that syllable onsets constitute potential alignment points for the mapping process. We present an overview of several studies using explicit ...

CASE REPORT A 38-year-old woman was admitted to the hospital because of sudden, right-sided weakness and impaired language expression and comprehension. The patient had a history of tuberculosis ten years prior and of thrombophlebitis in the lower-left limb five months prior. She was taking oral contraceptives. Three weeks before admission she started treatment with daily tranexamic acid (500 m...

Object tracking refers to spotting the presence of one or more objects of interest in each frame of a video. The task of object tracking is mainly useful in visual surveillance and scene understanding applications. With the increasing availability of rich video contents, new application areas are emerging every day. Generally, object tracking plays an intermediate role in many such applications...

The promiscuous binding behavior of bioactive compounds forms a mechanistic basis for understanding polypharmacological drug action. We present the development and prospective application of a computational tool for identifying potential promiscuous drug-like ligands. In combination with computational target prediction methods, the approach provides a working concept for rationally designing su...

BACKGROUND Caenorhbditis elegans has being vigorously used as a model organism in many research fields and often accompanied by administrating with various drugs. The methods of delivering drugs to worms are varied from one study to another, which make difficult in comparing results between studies. METHODOLOGY/PRINCIPAL FINDINGS We evaluated the drug absorption efficiency in C. elegans using...