نتایج جستجو برای: micb
تعداد نتایج: 187 فیلتر نتایج به سال:
Non-conventional MHC class I MIC molecules interact not with the TCR, but with NKG2D, a C-type lectin activatory receptor present on most NK, gammadelta and CD8(+) alphabeta T cells. While this interaction is critical in triggering/calibrating the cytotoxic activity of these cells, the actual extent of its in vivo involvement, in man, in infection, cancer or autoimmunity, needs further assessme...
Background: MICA and MICB are tightly regulated stress-induced proteins that trigger the immune system by binding to activating receptor NKG2D on cytotoxic lymphocytes. MICA highly polymorphic molecules with prevalent expression several types of solid tumors limited in normal/healthy tissues, making them attractive targets for therapeutic intervention....
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