Epilepsy is one of the most common neurological diseases, and current antiepileptic drugs fail to suppress seizure occurrence in around one third of epileptic patients. Curcumin is a phytochemical with promising effects on epilepsy treatment. However, its application has been hindered by its low bioavailability. In order to improve curcumin's anti-seizure properties, increasing its bioavailabil...

This short paper reviews two groups of enzymes designated as polyethylene terephthalate (PET) hydrolases: one consists thermophilic cutinases from microorganisms (actinomycetes and a fungus) the other mesophilic cutinases, representative which is IsPETase bacterium. From viewpoint that PET hydrolysis requires high temperature close to glass transition (65–70 °C in water) PET, are not suitable f...

Ganoderma lucidum (G. lucidum) is a mushroom-forming white rot fungus that contains a wide variety of bioactive components (glucans). In this study, G. lucidum was utilized for the extraction of polysaccharides by hot compressed water at a temperature of 160 o C and a pressure of 4.0 MPa using a semi-batch system. Under these conditions, thermal softening of G. lucidum occurred, allowing the re...

A rapid expansion of supercritical solution (RESS) technology was presented for the micronization of Chinese medicinal material. Magnolia bark extract (MBE) obtained by supercritical carbon dioxide (scCO(2)) extraction technology was chosen as the experimental material. RESS process produced 4.7 microm size MBE microparticles (size distribution, 0.2-24.1 microm), which was significantly smaller...

Griseofulvin (GF) is an antifungal drug whose pharmaceutical activity can be improved by particle size reduction. In this study the rapid expansion of supercritical solution (RESS) was employed to micronize GF. Carbon dioxide (CO2) with cosolvent acetone was chosen as a supercritical mixed solvent. The solubility of GF in supercritical CO2 with cosolvent acetone was measured using a dynamic app...