Injectable dermal filler materials consist of either fluids, biological fragments, or suspensions of particles or microspheres. Particles and microspheres are said to "migrate," but migration can occur only when they are injected into blood vessels. To evaluate biocompatibility and transport, five nonresorbable polymethylmethacrylate microspheres of various sizes, suspended in different carrier...

Nanofibrous hydrogel microspheres are formed by pH gelation of perylene diimide derivatives in emulsion droplets. These microspheres are freeze-dried and subsequently carbonized to produce discrete N-doped nanofibrous carbon microspheres. The carbon microspheres show high performance as electrode materials for supercapacitors.

in the long-term management of ulcerative colitis patients, repeat dosing maybe required. since 5-asa is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug delivery with fewer side effects and a higher efficacy. the aim of this study was to prepare and evaluate a double coated multiparticulate system for 5-asa deliver...

The aim of the study was to prepare site specific drug delivery of naproxen sodium using sodium alginate and Eudragit S-100 as a mucoadhesive and pH-sensitive polymer, respectively. Core microspheres of alginate were prepared by a modified emulsification method followed by cross-linking with CaCl2, which was further coated with the pH dependent polymer Eudragit S-100 (2.5 or 5 %) to prevent dru...

Measurement of regional myocardial blood flow (RMBF) is crucial in experimental studies of myocardial ischemia and reperfusion in dogs. The standard measurement technique uses radioactive microspheres; however, not all institutions are able to dispose of radioactive waste and therefore cannot make use of this method. We tested a new, nonradioactive microsphere, labeled with colors instead of nu...

The objective of this study was to evaluate the proliferation and chondrogenic differentiation of rat bone marrow-derived mesenchymal stem cells (MSCs) cultured with gelatin hydrogel microspheres of cell scaffold which can release transforming growth factor-beta1 (TGF-beta1). Gelatin was dehydrothermally cross-linked in different conditions in a water-in-oil emulsion state to obtain gelatin hyd...

In this paper, the effect of chitosan molecular weight on the characteristics (size, encapsulation efficiency, zeta potential, surface morphology and release rate) of vitamin C encapsulated tripolyphosphate cross-linked chitosan (TPP-chitosan) microspheres. The molecular weight of chitosan had a noticeable influence on the size, encapsulation efficiency, zeta potential, surface morphology and c...

Monodisperse biotinylated poly(styrene-co-N-acryloxysuccinimide) microspheres were synthesized in aqueous solutions with a two-step method. Upon the addition of avidin solutions of different concentrations in phosphate buffer into the dispersed biotinylated microspheres, the microspheres aggregated rapidly due to the high binding affinity between biotin and avidin. The hydrodynamic diameter of ...

Ferrocyanide-imprinted pyridine-carrying microspheres were prepared using ferrocyanide ions as a template. This method is based on a surface imprinting technique from the seed emulsion that consisted of 4-vinylpyridine (functional monomer), styrene, and butyl acrylate and a water mixture polymerization by a radical initiator. The ferrocyanide-imprinted microspheres had about 200 times higher ad...

BACKGROUND Cell-derived microvesicles (MVs) in biological fluids are studied for their potential role in pathological conditions. Flow cytometry is used to characterize MVs. Polystyrene microspheres are often used in flow cytometry to distinguish MV from cells by setting a 1-μm MV gate in a side-scatter (SSC) vs. forward-scatter (FSC) dot plot. Polystyrene microspheres, however, exhibit higher ...