Diabetes mellitus is a major health problem associated with microvascular and macrovascular complications, leading to increased morbidity and mortality. It is rapidly growing worldwide with a huge economical and social burden. Although prevention and treatment of diabetes and its complications play a key role in reducing its morbidity and mortality, they require an integrated team approach at n...

Type 2 Diabetes Mellitus is a heterogeneous condition characterized by the presence of both impaired insulin secretion and insulin resistance [1]. Diabetes care is complex and requires that many issues, beyond glycaemic control, be addressed [2]. They are prone to certain complications and evidence emerged in the 1990s supporting the benefits of glycaemic control as well as control of blood pre...

background: in addition to macrovascular and along with other microvascular complications, diabetic patients suffer from some common musculoskeletal complications. the aim of this study was to assess the prevalence of five musculoskeletal disorders of upper extremity including shoulder capsulitis (sc), limited joint mobility (ljm), dupuytren’s contracture (dc), carpal tunnel syndrome (cts), and...

BACKGROUND Microvascular and macrovascular abnormalities are frequently found on noninvasive tests performed in older adults. Their prognostic implications on disability and life expectancy have not been collectively assessed. METHODS This prospective study included 2,452 adults (mean age: 79.5 years) with available measures of microvascular (brain, retina, kidney) and macrovascular abnormali...

The prevalence of type 2 diabetes mellitus (T2DM) is steadily increasing, mostly due to a combination of obesity, urbanization, and ageing population.1,2 In parallel, the prevalence of its macrovascular and microvascular complications, such as diabetic nephropathy (DN), which occurs in 20 to 40% of type 2 diabetic patients, has risen.3,4 Despite efforts made to slow the progression of DN, this ...

Diabetes mellitus is a lifelong, incapacitating metabolic disease associated with chronic macrovascular complications (coronary heart disease, stroke, and peripheral vascular disease) and microvascular disorders leading to damage of the kidneys (nephropathy) and eyes (retinopathy). Based on the current trends, the rising prevalence of diabetes worldwide will lead to increased cardiovascular mor...

The disease burden associated with Type-2 Diabetes Mellitus (T2DM) on a daily basis, which makes it necessary to develop new diagnostic modalities for T2DM. recently emerging molecular biomarkers have high predictive potential, enhanced efficacy, therapeutic and ability assess progression complications. In recent times we some epigenetic like miRNAs shown promise in various diseases including T...