The stability constant Kf for the complexation of Ag(Ⅰ) metal ion with Midodrine hydrochloride were determinedby spectrophotometric method at room temperature .The colored complexes measured 300 nm. found to be 5.47 by mole ratio method. stoichiometry formed between drug and Ag (Ⅰ) are 1:1 M/L ratio. Silver conjugated Nano synthesized characterized UV/Visible spectroscopy, SEM, XRD FT-IR. spect...

This paper reports the construction and evaluation of two ion selective electrodes for the determination midodrine hydrochloride (MD) by direct potentiometry in pure drug substance and in tablet formulations. Precipitation based technique was used for fabrication of the first membrane sensor (sensor 1) using phosphotungestate (PT) and dioctylphthalate (DOP) as cation exchanger and solvent media...

CASE PRESENTATION — A 26year-old woman with “brittle” type 1 diabetes and severe CAN experienced sudden cardiac death. She had a 16-year history of poor diabetes control presenting with wide blood glucose fluctuations, recurrent episodes of severe hypoglycemia, and hypoglycemia unawareness. Over time she developed persistent orthostatic hypotension with daily falls in systolic blood pressure ra...

Hepatorenal syndrome (HRS) is a grave complication of end-stage liver disease and is associated with a very high mortality. This case report described a 42-year-old female with advanced alcohol-induced cirrhosis who developed HRS that was initially treated with Midodrine and Octreotide but renal function continued to deteriorate. Vasopressin therapy was added and HRS was successfully reversed. ...