نتایج جستجو برای: mifepristone

تعداد نتایج: 1217  

Journal: :Journal of cancer science & therapy 2012
Carlos M Telleria

In the mid-1980s, a French company geared its efforts toward developing a synthetic steroid capable of blocking the glucocorticoid receptor in order to potentially treat Cushing’s syndrome. Preclinical studies revealed that the compound developed, termed RU-38486, was indeed a potent antiglucocorticoid agent [1], yet with a caveat: if given to pregnant animals, it terminated pregnancy [2-4]. Th...

2012
Josep L Carbonell Esteve Ana M Riverón Mariela Cano Alma I Ortiz Aleta Valle Carlos S Texidó Giuseppe Tomasi

OBJECTIVES To evaluate the efficacy and safety of 2.5 mg and 5 mg mifepristone during 3 months for the treatment of uterine fibroids before surgery. DESIGN Multicenter randomized clinical trial. LOCATIONS Eusebio Hernández Hospital, Havana, Cuba and the Alemán Hospital, Managua, Nicaragua. SUBJECTS Included in the study were 146 women with symptomatic uterine fibroids. TREATMENT GROUP I...

Journal: :Contraception 2013
Jamila B Perritt Anne Burke Alison B Edelman

The need to interrupt a pregnancy between 24 and 28 weeks of gestation is uncommon and is typically due to fetal demise or lethal anomalies. Nonetheless, treatment options become more limited at these gestations, when access to surgical methods may not be available in many circumstances. The efficacy of misoprostol with or without mifepristone has been well studied in the first and earlier seco...

Journal: :Social science & medicine 2003
Carole Joffe Tracy A Weitz

Mifepristone, also known as RU-486, and in the US known as "the French abortion pill", finally received FDA approval in the United States in September 2000. This paper discusses the steps now in process to integrate this drug into mainstream healthcare and the sociological implications of those efforts. Each of the steps that is normally taken to introduce a newly approved medication in the US ...

2015
Josep Lluis Carbonell Ramon Garcia Adriana Gonzalez Andres Breto Carlos Sanchez

PURPOSE To estimate the efficacy and safety of 5 mg and 10 mg mifepristone for emergency contraception up to 144 hours after unprotected coitus. METHODS This double-blind randomized clinical trial was carried out at Eusebio Hernandez Hospital (Havana, Cuba). A total of 2,418 women who requested emergency contraception after unprotected coitus received either 5 mg or 10 mg mifepristone. The va...

Journal: :Human reproduction 2005
C Fiala M L Swahn O Stephansson K Gemzell-Danielsson

BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the biosynthesis of prostaglandins and concerns have been expressed that they might attenuate the effects of exogenous prostaglandins. This randomized study was conducted to evaluate whether NSAID given during medical abortion with mifepristone/misoprostol in the second trimester has a negative effect on the efficacy of the abort...

Journal: :Molecular human reproduction 2002
A Christow X Sun K Gemzell-Danielsson

It is likely that mifepristone or levonorgestrel in the future will find extended use for contraceptive purposes. It is therefore essential to characterize the modes of action of these compounds. To assess the effect on the human Fallopian tube, 24 women with regular menstrual cycles and proven fertility, admitted to the hospital for voluntary sterilization by laparoscopic technique, were rando...

Journal: :Human reproduction 2009
J Chai O S Tang Q Q Hong Q F Chen L N Cheng E Ng P C Ho

BACKGROUND The conventional timing of misoprostol administration after mifepristone for second trimester medical abortion is 36-48 h, but simultaneous administration, which may make the regimen more convenient, has not been studied. The objective of this randomized comparison study is to compare two intervals of administration of misoprostol after pretreatment with mifepristone for second trime...

Journal: :Contraception 2011
Vivian Chi Yan Lee Oi Sang Tang Ernest Hung Yu Ng William Shu Biu Yeung Pak Chung Ho

BACKGROUND Letrozole is a third-generation selective aromatase inhibitor. Animal data suggested that it might be useful in medical abortion. We performed two pilot studies to assess the feasibility of using letrozole in combination with either mifepristone or misoprostol for termination of pregnancy up to 63 days. STUDY DESIGN We recruited 40 subjects who requested legal termination of pregna...

Journal: :Contraception 2013
Elizabeth G Raymond Caitlin Shannon Mark A Weaver Beverly Winikoff

BACKGROUND The dose of mifepristone approved by most government agencies for medical abortion is 600 mg. Our aim was to summarize extant data on the effectiveness and safety of regimens using the widely recommended lower mifepristone dose, 200 mg, followed by misoprostol in early pregnancy and to explore potential correlates of abortion failure. STUDY DESIGN To identify eligible reports, we s...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید