The use of DNA probes to monitor minimal residual disease in childhood acute lymphoblastic leukaemia. A. The polymerase chain reaction: a new tool for the detection of minimal residual disease in hae-matological malignancies. Tournay 0, et al. Detection of minimal disease in hematopoietic malignancies of the B lineage by using third-complimentarity-determining region (CDR-III) specific probes. ...