TOPIC: Cardiovascular Disease TYPE: Medical Student/Resident Case Reports INTRODUCTION: Minoxidil, a directly acting vasodilator used in treating resistant hypertension, has notable side effects including salt and fluid retention, pericarditis, occasionally pericardial effusion which may progress to tamponade rare cases. Patients with advanced renal impairment are at higher risk for developing ...

In spontaneously hypertensive rats (SHR), the progression (or absence of regression) of cardiac hypertrophy despite adequate blood pressure (BP) control by arterial vasodilators has been attributed to increased cardiac sympathetic activity. We evaluated changes in indices of general and cardiac sympathetic tone in relation to changes in cardiac anatomy during treatment of normotensive rats and ...

Sir, We report a case of a 48-year-old male with end-stage renal disease secondary to focal segmental glomerular sclerosis, who began continuous ambulatory peritoneal dialysis (PD) in June 2002. Three months later, minoxidil 5mg/day was introduced because of uncontrolled hypertension. Oedema and weight gain appeared in spite of 3 l/day net ultrafiltration on PD. Left pleural effusion associated...

BACKGROUND The role of nonhemodynamic cardiac trophic mechanisms differs not only between different models of cardiac hypertrophy but also within the same model for development versus maintenance of cardiac hypertrophy. Our previous studies pointed to a major role for the renin-angiotensin system (RAS) as a cardiac trophic stimulus in the remodeling of the heart in response to volume overload b...

In the present study we tested the hypothesis whether an angiotensin AT2 receptor-mediated stimulation of the bradykinin (BK)/nitric oxide (NO) system can account for the effects of AT1 receptor antagonism on aortic cGMP described previously in SHRSP. Adult SHRSP were treated for 4 hours with angiotensin II (ANG II) (30 ng/kg per min IV) or vehicle (0.9% NaCl I.V.). Animals were pretreated with...

The effectiveness of three adhesive tapes, 3M’s No. 810, No. 845 and No. 850, in stripping stratum comeum from hairless mouse skin. was compared by measuring transdermal water loss (TEWL) and distribution profiles of a marker, minoxidil, from a solution formulation. While No. 850 tape failed to increase TEWL perceptively even after 24 strippings, both No. 810 and 845 tapes effectively removed t...

Objective: The purpose of this study was to formulate a phytosome lotion from Mangkokan leaf using green solvent extraction. Methods: Ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate, combined with microwave-assisted extraction, used obtain flavonoid compounds. extract formulated into three different ratios phospholipon (1:0.5), (1:1), and (1:2). Three formulas were analyzed identify...