نتایج جستجو برای: mitochondrial disease

تعداد نتایج: 1603053  

Journal: :Archives of Disease in Childhood 1988

Journal: :Journal of Inherited Metabolic Disease 2016

Journal: :Current Medicinal Chemistry 2019

Journal: :Nature Reviews Endocrinology 2016

Journal: :iranian journal of pharmaceutical sciences 0
ahmad salimi department of pharmacology and toxicology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran. department of pharmacology and toxicology, school of pharmacy, ardabil university of medical science, ardabil, iran. students research committee, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. melina ramandoost department of pharmacology and toxicology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran jalal pourahmad jaktaji department of pharmacology and toxicology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran

6- mercaptopurine (6-mp) is widely used in clinic as an immunosuppressive for treatment of acute lymphocytic leukemia, crohn's disease, and ulcerative colitis with documented unpredictable hepatotoxicity. the potential molecular cytotoxic mechanisms of 6-mp against isolated rat hepatocytes were searched in this study using “accelerated cytotoxicity mechanism screening (acms)” techniques. t...

Journal: :genetics in the 3rd millennium 0
مسعود هوشمند masoud houshmand asst prof molecular genetics, national institute for genetic engineering and biotechnology / special medical center, tehran, iran محمد حسین صنعتی mohammad hossein sanati ایران راشدی iran rashedi فاطمه شریف پناه fatemeh sharifpanah الهام اصغری elham asghari جمشید لطفی jamshid lotfi

the hypothesis that mitochondrial genes may be implicated in susceptibility to multiple sclerosis (ms) is supported by an increasing number of case reports on lebers hereditary optic neuropathy (lhon)-associated mitochondrial dna (mtdna) point mutations in patients with ms. a number of mtdna mutations with primary pathogenic significance for lhon, a maternally inherited disease causing severe b...

Journal: :genetics in the 3rd millennium 0
مسعود هوشمند masoud houshmand asst prof molecular genetics, national institute for genetic engineering and biotechnology / special medical center, tehran, iran محمد حسین صنعتی mohammad hossein sanati ایران راشدی iran rashedi فاطمه شریف پناه fatemeh sharifpanah الهام اصغری elham asghari جمشید لطفی jamshid lotfi

the hypothesis that mitochondrial genes may be implicated in susceptibility to multiple sclerosis (ms) is supported by an increasing number of case reports on lebers hereditary optic neuropathy (lhon)-associated mitochondrial dna (mtdna) point mutations in patients with ms. a number of mtdna mutations with primary pathogenic significance for lhon, a maternally inherited disease causing severe b...

2014
Maurizio Moggio Irene Colombo Lorenzo Peverelli Luisa Villa Rubjona Xhani Silvia Testolin Salvatore Di Mauro Monica Sciacco

Mitochondrial diseases are a heterogeneous group of progressive, genetically transmitted, multisystem disorders caused by impaired mitochondrial function. The disease course for individuals with mitochondrial myopathies varies greatly from patient to patient because disease progression largely depends on the type of disease and on the degree of involvement of various organs which makes the prog...

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