Oxymatrine, a potent monosomic alkaloid extracted from Chinese herb Sophora japonica (Sophora flavescens Ait.). possesses anti-inflammatory activittyes.  This study was designed to investigate the effects of oxymatrine on nuclear factor–kappa B (NF-κB) and mitogen-activated protein kinase (MAPK)-dependent inflammatory responses in lipopolysaccharide (LPS)-activated microglia. In this paper, BV2...

Purpose: To present a case of chemotherapy regimen combining fibroblast growth factor receptor (FGFR) and mitogen-activated protein kinase (MEK) inhibitor leading to serous retinopathy. Methods: A retrospective chart review single was performed. Results: 67-year-old man with pancreatic prostate cancer developed bilateral multifocal pockets subretinal fluid while on an experimental MEK (trametin...

The Rat sarcoma virus (RAS) family of proteins, which includes the Kristen (KRAS), is linked to nearly one-fourth all human cancers. KRAS mutations, in particular, are associated with Non-Small Cell Lung Carcinoma (NSCLC), colorectal cancer, adenocarcinomas, ovarian carcinoma, and endometrial tumors. activates 80 different signaling pathways, including Mitogen-activated protein kinases (MAPK) P...

sepsis as the host responsive syndrome is one of the main concerning issues and costly disease on intensive care unit (icu) in the 21st century. epidemiological studies have showed that mortality rates of sepsis in icu and hospitals among 37 countries were 39.2% and 49.6% respectively [1].  complicated nature of sepsis is still not well understood and this makes it hard to treat and manage. acc...

Objective(s): The novel 1,5-diaryl-1,4-pentadien-3-one derivatives were studied for analgesic, anti-inflammatory and anticancer potential to establish their role in pain, inflammatory disorders and cancer.Materials and Methods: Two 1,5- diaryl-1,4-pentadien-3-one derivatives: (1E,4E)- 5-(4-fluoro phenyl)-1-(4-methoxyphenyl)- 2-methylpenta-1,4-dien-3-one (A2K2A17) and  (1E,4E)-5-(4-nitrophenyl)-...

Liver fibrosis is an outcome of many chronic liver diseases and often results in cirrhosis, failure even hepatocarcinoma. Zhuyu zhenggan decoction as a classical traditional Chinese medicine formula used to clinical practice while its mechanism unclear. The aim this study was investigate the anti-fibrosis effect explore molecular mechanisms by combining network pharmacology animal experiment. c...